疏肝解郁逐瘀汤联合来曲唑在多囊卵巢综合征(PCOS)不孕症中的应用

Application of Shugan Jieyu Zhuyu Decoction Combined with Letrozole in Patients with Infertility Caused by PCOS

目的探讨疏肝解郁逐瘀汤联合来曲唑在多囊卵巢综合征(PCOS)所致不孕症患者中的应用效果。方法前瞻性选取医院2018年8月—2020年8月治疗的78例PCOS所致不孕症患者作为研究对象,采用交替分组法将其分为对照组和观察组,各39例。对照组采用来曲唑治疗,观察组在对照组基础上,采用疏肝解郁逐瘀汤治疗,治疗4个月后,比较两组临床疗效,并对比两组治疗前、4个月后性激素水平[卵泡生成激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))]、子宫内膜厚度及卵巢体积,比较两组治疗3个月后妊娠率,以及治疗期间不良反应。结果治疗4个月后,观察组临床总有效率高于对照组(P<0.05);治疗4个月后,两组FSH、E_(2)水平及子宫内膜厚度、卵巢体积均高于治疗前,且观察组高于对照组,LH水平低于治疗前,且观察组低于对照组(P<0.05);观察组治疗后3个月内妊娠率高于对照组(P<0.05);两组未见严重不良反应。结论疏肝解郁逐瘀汤联合来曲唑治疗PCOS所致不孕症患者效果较好,能够有效改善患者性激素水平,增加子宫内膜厚度,增大卵巢体积,提高妊娠率,且安全性较好。

Objective To explore the application effect of Shugan Jieyu Zhuyu Decoction combined with letrozole in patients with infertility caused by polycystic ovary syndrome(PCOS). Methods A total of 78 cases of patients with infertility caused by PCOS treated in our hospital from August 2018 to August 2020 were selected as the research subjects. The alternating grouping method was used to divide them into a control group and an observation group with 39 cases in each group. The control group was treated with letrozole, and the observation group was treated with Shugan Jieyu Zhuyu Decoction on the basis of the control group. After 4 months of treatment, the clinical effects of the two groups were compared. The sex hormone levels[follicle stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E_(2))], endometrial thickness and ovarian volume of the two groups before and 4 months after treatment were compared. The pregnancy rate after 3 months of treatment and adverse reactions during treatment were compared between the two groups. Results After 4 months of treatment, the total effective rate of the observation group was higher than that of the control group(P<0.05). After 4 months of treatment, the levels of FSH and E_(2)as well as the endometrial thickness and ovarian volume in both groups were higher than those before treatment, and the observation group’s levels were higher than those of the control group. The LH level was lower than that before treatment, and the observation group’s level was lower than that of the control group(P<0.05). The pregnancy rate of the observation group was higher than that of the control group within 3 months after treatment(P<0.05). No serious adverse reactions were found in both groups. Conclusion Shugan Jieyu Zhuyu Decoction combined with letrozole has better effect in the treatment of patients with infertility caused by PCOS, which can effectively improve the level of sex hormone, increase the thickness of endometrium and the volume of ovary, improve the pregnancy rate, and has higher safety.