北京市首例发热伴血小板减少综合征本土病例的调查

Investigation on the first local case of severe fever with thrombocytopenia syndrome in Beijing

目的了解2021年10月北京市首例发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)本土病例的发病及流行病学特点,为制定北京市的防控策略提供依据。方法采用流行病学调查方法,分析流行病学特点,采用实时荧光定量PCR和ELISA法分别检测患者血清中发热伴血小板减少综合征病毒(SFTSV)核酸和抗体,并进行媒介和宿主动物的调查。结果调查结果显示,患者多年未出北京,在患者血清标本中检测到SFTSV病毒核酸及IgM抗体,病毒载量达1.9×10^(4) TCID_(50)/mL,媒介生物调查捕获5只蜱虫的SFTSV核酸检测为阴性;宠物犬的血液中亦未检测到SFTSV核酸及抗体。结论2021年10月报告的这例SFTS本土病例为北京市首次报道,今后应加强对该病的监测以及媒介生物的监测。

Objective To study the clinical features and epidemiological characteristics of the first local case of severe fever with thrombocytopenia syndrome(SFTS)on October 2021 in Beijing,so as to provide basis for formulating the prevention and control strategy.Methods The epidemiological characters of the case was analyzed by epidemiological investigation methods.Real time fluorescent quantitative PCR and ELISA were used to detect nucleic acid of severe fever with thrombocytopenia syndrome virus(SFTSV)and antibodies against the virus.The vectors and host animals were also investigated.Results The investigation results indicated that the patient haven’t leave from Beijing for many years.Nucleic acid of SFTSV and IgM antibody were detected in the serum sample and the viral load was 1.9×10^(4) TCID_(50)/ml.The 5 ticks captured during vector survey were negative for SFTSV nucleic acid.The blood sample of the pet dog was also negative for both SFTSV nucleic acid and antibody against the virus.Conclusions The SFTS case on October 2021 was the first local case reported in Beijing.Surveillance for SFTS and vectors should be strengthened.