钇[^(90)Y]树脂微球介入治疗的放射防护评估

Radiation protection assessment for interventional therapy with ^(90)Y resin microspheres

目的对钇[^(90)Y]树脂微球介入治疗项目的辐射安全性进行全面评估,为放射防护工作提供参考依据。方法利用相关文献和^(90)Y-树脂微球药品说明书中的数据,估算患者^(90)Y-树脂微球3 GBq药量介入治疗时,排泄物中的^(90)Y含量和患者对周围人员的照射剂量,并结合国家相关标准法规评估^(90)Y-树脂微球介入治疗项目的辐射安全性。结果给出了患者住院期间,医护人员和同室病友的受照剂量,均在职业人员及公众的约束值内;评估了患者排泄物直接排入普通下水道的安全性,满足我国现行的排放控制值;给出了患者出院后对家属、公众同事的照射剂量,在允许的约束值内;并对孕妇及3岁以下儿童应避免接触的情况列出了避免接触的时间和距离要求。结论^(90)Y虽只发射β射线,但在人体内会因韧致辐射而发出连续X射线;在普通病房开展钇[^(90)Y]树脂微球住院治疗项目就辐射安全性而言是可行的,对非放射性工作医护人员需注意控制病人数量;患者出院后的活动除要避免接触孕妇和3岁以下儿童外,可以不受任何限制。

Objective To comprehensively evaluate the radiation safety of interventional therapy with yttrium(^(90)Y)resin microspheres,and to provide a reference basis for radiation protection.Methods Using the data from related literature and^(90)Y resin microsphere drug instructions,the urinary excretion of ^(90)Y and the exposure dose to surrounding personnel during interventional therapy with 3 GBq ^(90)Y resin microspheres were estimated.The radiation safety of interventional therapy with^(90)Y resin microspheres was also evaluated according to the related Chinese standards and regulations.Results The exposure doses to the medical staff and the wardmates caused by the patient during hospitalization were obtained,which were within the constraint values of professionals and the public;the safety of the patients’excreta directly discharged into ordinary sewers was also evaluated so that it met the current discharge control value in China.The exposure doses to family members and colleagues after the patients were discharged from the hospital were calculated,which were within the allowed constraint value;the time and distance requirements for avoiding contact with the pregnant women and children under 3 years of age were listed in this study.Conclusion Although ^(90)Y only emitsβ-ray,continuous X-ray will be emitted in the patient’s body due to bremsstrahlung radiation.The hospitalization treatment project of ^(90)Y resin microspheres in the general ward is feasible in terms of radiation safety.The medical staff who are not radiation workers should pay attention to controlling the number of patients.The post-discharge activities of patients can be unrestricted except for contact with pregnant women and children under 3 years of age.