胞磷胆碱联合美金刚对血管性痴呆患者认知功能及日常生活能力的影响

Effects of Citicoline Combined with Memantine on Cognitive Function and Daily Life of Vascular Dementia Patients

目的探讨胞磷胆碱联合美金刚对血管性痴呆患者认知功能及日常生活能力的影响。方法选取2019年8月至2020年8月中铁十九局集团有限公司职工中心医院收治的血管性痴呆患者82例作为研究对象,按随机数字表法分为对照组与观察组,各41例。对照组予以美金刚治疗,观察组采用美金刚与胞磷胆碱联合治疗。比较两组治疗前后认知功能、日常生活能力、氧化应激指标及不良反应。结果治疗前,两组蒙特利尔认知评估量表(Mo CA)、日常生活活动能力量表(ADL)评分比较,差异无统计学意义(P>0.05);治疗后,观察组Mo CA、ADL评分分别为(29.84±3.76)分、(68.59±4.23)分,高于对照组的(22.56±3.49)分、(59.44±4.57)分,差异有统计学意义(P<0.05);治疗前,两组丙二醛(MDA)、同型半胱氨酸(Hcy)、超氧化物歧化酶(SOD)水平比较,差异无统计学意义(P>0.05);治疗后,观察组MDA、Hcy水平分别为(6.35±0.85)μmol/L、(31.39±9.27)μmol/L,低于对照组的(7.11±0.87)μmol/L、(42.24±11.38)μmol/L,SOD水平(112.28±15.37)U/L,高于对照组的(92.34±12.44)U/L,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论胞磷胆碱联合美金刚治疗血管性痴呆患者能够改善其认知功能,减轻氧化应激反应,提高日常生活能力,促进病情转归。

Objective To investigate the effects of citicoline combined with memantine on cognitive function and daily life of patients with vascular dementia. Methods A total of 82 patients with vascular dementia admitted to Department of Internal Medicine Three Wards, China Railway Nineteenth Bureau Group Co., Ltd. Staff Central Hospital from August 2019 to August 2020 were selected as the research objects and were randomly divided into a control group and an observation group, with 41 cases in each group. The control group was treated with memantine, and the observation group was treated with memantine and citicoline.The cognitive function, daily life ability, oxidative stress index and adverse reactions were compared and before and after treatment.Results Before treatment, the Montreal Cognitive Assessment Scale(MoCA) and the Daily Activity Scale(ADL) were compared between the 2 groups, the difference was not statistically significant(P>0.05);after treatment, the MoCA、ADL scores were(29.84±3.76),(68.59±4.23), higher than(22.56±3.49),(59.44±4.57) in the control group, there was a statistical difference(P<0.05);Before treatment, there was no significant difference in the levels of malondialdehyde(MDA), homocysteine(Hcy) and superoxide dismutase(SOD) between the 2 groups(P>0.05);After treatment, the MDA、Hcy levels of the observation group were(6.35±0.85)μmol/L、(31.39±9.27)μmol/L, lower than those of the control group(7.11±0.87)μmol/L、(42.24±11.38)μmol/L, SOD level(112.28±15.37)U/L, was higher(92.34±12.44)U/L than control group, there was a statistical difference(P<0.05);the incidence of adverse reactions was similar between the 2 groups, and there was no statistical difference(P>0.05). Conclusion Citicoline combined with memantine can improve cognitive function in patients with vascular dementia, relieve oxidative stress, improve the ability of daily life, and promote the outcome of the disease.