醒脑静注射液联合吡拉西坦治疗急性脑出血患者的疗效

Clinical Observation of Xingnaojing Injection Combined with Piracetam in the Treatment of Patients with Acute Cerebral Hemorrhage

目的探讨醒脑静注射液联合吡拉西坦治疗急性脑出血患者的疗效。方法选取2019年1月至2020年6月盘锦市人民医院收治的60例急性脑出血患者作为研究对象,根据治疗方法不同分为对照组与观察组,各30例。对照组给予吡拉西坦治疗,观察组采用醒脑静注射液联合吡拉西坦治疗,比较两组的治疗结果。结果对照组和观察组治疗有效率分别为80.0%和93.3%,观察组显著高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组美国国立卫生研究院卒中量表(NIHSS)评分(9.1±1.2)分更低,蒙特利尔认知评估量表(Mo CA)评分(25.2±3.1)分更高,差异有统计学意义(P<0.05)。治疗后,观察组神经元特异性烯醇化酶水平(48.2±3.5)ng/L及胶质纤维酸性蛋白水平(8.1±1.1)ng/L更低,差异有统计学意义(P<0.05)。结论对于急性脑出血患者,应用醒脑静注射液联合吡拉西坦治疗可以有效改善患者神经功能、认知功能,提高患者治疗效果及预后效果。

Objective To explore the therapeutic effect of Xingnaojing Injection combined with piracetam in the treatment of patients with acute cerebral hemorrhage. Methods A total of 60 patients with acute cerebral hemorrhage admitted to Panjin People’s Hospital from January 2019 to June 2020 were selected as the research objects. According to the different treatment methods, they were divided into a control group and an observation group, with 30 cases in each group. The control group was treated with piracetam, and the observation group was treated with Xingnaojing Injection combined with piracetam. The treatment results of the 2 groups were compared. Results The effective rates of treatment in the control group and observation group were 80.0% and 93.3%, respectively. The observation group was significantly higher than the control group, and the difference was statistically significant(P<0.05). After treatment, the National Institutes of Health Stroke Scale(NIHSS) score(9.1±1.2) in the observation group was lower, and the Montreal Cognitive Assessment Scale(MoCA) score(25.2±3.1) was higher, and the difference was statistically significant.(P<0.05). After treatment, the neuron-specific enolase level(48.2±3.5) ng/L and the glial fibrillary acidic protein level(8.1±1.1) ng/L of the observation group were lower, and the difference was statistically significant(P<0.05). Conclusion For patients with acute cerebral hemorrhage, the application of Xingnaojing Injection combined with piracetam treatment can effectively improve the patient’s neurological function and cognitive function, and improve the treatment effect and prognosis effect of the patient.