NF-κB在前列腺增生中的调控作用及研究进展

Regulatory effect of NF-κB on prostatic hyperplasia:Progress in researches

良性前列腺增生(BPH)是一种多发于中老年男性的慢性疾病,其确切发病机制尚不完全清楚。核转录因子κB(NF-κB)是一类能够特异性结合靶基因并介导其转录、表达的调控因子,具有分布广泛、功能多样的特征,逐渐成为细胞增殖异常相关疾病和炎症性疾病的研究热点。近年来一些研究表明,NF-κB可通过调节炎症反应、影响内源激素水平并干预细胞凋亡等方式,参与激素依赖性器官的生长和发育过程,如前列腺。但关于NF-κB信号通路与BPH调控关系的相关研究却鲜有报道,本文概括了NF-κB信号通路的激活方式,并针对其在BPH中的调控途径进行综述,以期为BPH防治提供参考。

Benign prostatic hyperplasia(BPH)is a chronic disease,and its exact pathogenesis is not fully clear.Nuclear factor-kappa B(NF-κB),a regulatory factor that can specifically bind target genes and mediate their transcription and expression,is characterized by wide distribution and multiple functions and gradually becoming a hotspot in studies of abnormal cell proliferation-associated diseases and inflammatory diseases.Recent studies have shown that NF-κB is involved in the growth and development of hormone-dependent organs,such as the prostate,by regulating inflammatory response,disturbing endogenous hormone levels and interfering with cell apoptosis.However,few reports are seen on the relationship between NF-κB signaling pathways and BPH.This review outlines the activation of NF-κB and its regulatory pathways in BPH,expecting to provide some reference for the prevention and treatment of BPH.