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COOK球囊联合雌孕激素在中重度宫腔粘连患者宫腔镜下冷刀术后的应用效果 被引量:5

Effectiveness of COOK balloon combined with estrogen and progesterone after hysteroscopic cold knife operation for moderate to severe intrauterine adhesions
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摘要 目的评价COOK球囊联合雌孕激素在中重度宫腔粘连患者宫腔镜下冷刀术后的应用效果。方法抽取2017年5月至2020年5月临汾市中心医院收治的中重度宫腔粘连患者84例,均行宫腔镜下冷刀术,依据术后措施分为两组。观察组42例术后放置COOK球囊联合雌孕激素治疗,对照组42例术后放置节育器联合雌孕激素治疗。随访1年以上,比较两组宫腔形态及月经改善情况、白细胞及中性粒细胞计数变化及术后1年妊娠情况。结果观察组宫腔形态改善率高于对照组(χ^(2)=5.516,P<0.05),观察组月经总改善率高于对照组(χ^(2)=6.804,P<0.05)。治疗前后,两组白细胞计数、中性粒细胞计数比较,均无统计学差异(P均>0.05)。随访1年,观察组妊娠率为42.86%(18/42),高于对照组的21.43%(9/42),χ^(2)=6.072,P<0.05。结论中重度宫腔粘连患者宫腔镜下冷刀术后给予雌孕激素与COOK球囊处理,可改善宫腔形态与月经状况,且能提高妊娠率。 Objective To explore the effectiveness of COOK balloon combined with estrogen and progesterone after hysteroscopic cold knife operation for moderate to severe intrauterine adhesions.Methods 84 patients with moderate to severe intrauterine adhesions were selected for the study.All patients underwent hysteroscopic cold knife operation.According to postoperative measures,they were divided into two groups.After hysteroscopic cold knife operation,42 patients in the observation group was placed with COOK balloon,and supplemented with estrogen and progesterone,while 42 patients in the control group received IUD,and supplemented with estrogen and progesterone.Both groups were followed up for more than 1 year,the improvement of the uterine cavity morphology and menstruation,the changes of white blood cells and neutrophils,and the 1-year follow-up of pregnancy were compared between two group.Results The total recovery rate of uterine cavity morphology in the observation group was higher than that in the control group(χ^(2)=5.516,P<0.05),and the total menstrual improvement rate in the observation group was higher than that in the control group(χ^(2)=6.804,P<0.05).After treatment,the white blood cell count and neutrophil count in the two groups were compared,t=0.427,0.502,P>0.05.After 1 year of follow-up,the pregnancy rate in the observation group was 42.86%(18/42),which was higher than the 21.43%(9/42)in the control group,χ^(2)=6.072,P<0.05.Conclusions The administration of estrogen,progesterone and COOK balloon after moderate to severe intrauterine adhesions can improve the uterine cavity shape and menstrual condition,and increase the pregnancy rate.
作者 张郭丽 Zhang Guoli(Department of Gynecology,Linfen Central Hospital,Linfen 041000,China)
出处 《中国实用医刊》 2021年第22期50-52,共3页 Chinese Journal of Practical Medicine
关键词 孕激素 COOK球囊 雌激素 中重度宫腔粘连 Progesterone COOK balloon Estrogen Moderate to severe intrauterine adhesions
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