注射用奥美拉唑钠联合垂体后叶素治疗急性上消化道出血的效果观察

Efficacy of omeprazole sodium for injection combined with pituitrin in the treatment of acute upper gastrointestinal bleeding

目的探讨注射用奥美拉唑钠联合垂体后叶素治疗急性上消化道出血的临床效果。方法抽取2020年5月至2021年5月郑州市第七人民医院收治的急性上消化道出血患者84例,采用随机数字表法分为对照组与观察组,每组42例。两组患者均接受常规治疗,在此基础上,对照组接受垂体后叶素治疗,观察组接受注射用奥美拉唑钠联合垂体后叶素治疗。治疗3 d后比较两组患者临床疗效;记录患者止血时间、输血量及住院时间;比较两组治疗前、治疗3 d时凝血功能指标;记录治疗期间不良反应发生情况。结果治疗3 d,观察组总有效高于对照组(P<0.05);观察组止血及住院时间短于对照组,输血量少于对照组(P<0.05);治疗3 d,两组D-二聚体(D-D)低于治疗前,纤维蛋白原(Fib)高于治疗前,活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)短于治疗前,且观察组D-D低于对照组,Fib高于对照组,APTT、PT短于对照组(P<0.05);治疗期间,两组不良反应发生率比较,P>0.05。结论注射用奥美拉唑钠联合垂体后叶素能够有效缩短急性上消化道出血患者止血时间及住院时间,减少输血量,利于改善患者凝血功能,疗效确切。

Objective To investigate the clinical efficacy of omeprazole sodium for injection combined with pituitrin in the treatment of acute upper gastrointestinal bleeding.Methods A total of 84 patients with acute upper gastrointestinal bleeding admitted to the the 7th People’s Hospital of Zhengzhou from May 2020 to May 2021 were selected,a random number table method was used to divide them into two groups,with 42 cases in each group.Both groups received conventional treatment,on this basis,the control group received pituitrin treatment,the observation group received omeprazole sodium for injection combined with pituitrin treatment.The clinical efficacy of patients in the two groups was compared after 3 days of treatment;the hemostasis time,blood transfusion volume and hospitalization time of patients were recorded;the coagulation function indexes of the two groups were compared before and 3 days after treatment;the adverse reactions were recorded during treatment.Results After 3 days of treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05);the hemostatic time and hospitalization time of the observation group were shorter than those of the control group,the amount of blood transfusion was less than that of the control group(P<0.05);after 3 days of treatment,D-Dimer(D-D)of both groups was lower than that before treatment,fibrinogen(Fib)was higher than that before treatment,activated partial thromboplastin time(APTT)and prothrombin time(PT)were shorter than before treatment,D-D of the observation group was lower than that of the control group,FIB was higher than that of the control group,APTT and PT were shorter than those of the control group(P<0.05);during the treatment,the incidence of adverse reactions was compared between the two groups,P>0.05.Conclusions Omeprazole sodium for injection combined with pituitrin can effectively shorten the hemostatic time and hospitalization time of patients with acute upper gastrointestinal hemorrhage,and reduce the amount of blood transfusion,which is beneficial to improve the coagulation function of patients with definite efficacy.