吉西他滨相关肾损害

Gemcitabine-associated thrombotic microangiopathy

青年男性患者,确诊胰腺癌后给予吉西他滨联合白蛋白紫杉醇化疗半年,出现双下肢水肿、少尿伴血压升高,实验室检查发现大量蛋白尿、血清肌酐升高,肾活检组织学为血栓性微血管病,结合临床,考虑吉西他滨相关肾损害。

A 36-year old young man treated with gemcitabine and paclitaxel for half a year after the diagnosis of pancreatic cancer, presented with bilateral lower extremities edema, oliguria and hypertention.Laboratory examinations showed severe proteinuria and elevated serum creatinine. Renal biopsy revealed thrombotic microangiopathy. The final diagnosis was gemcitabine related kidney impairment.