女性绝经期激素替代治疗的争议和共识

Controversies and consensus on menopause hormone therapy in women during menopause

绝经期是女性生命中的一个重要且漫长的转变,可以引起骨质疏松等一系列临床症状,严重损害女性在该特殊时期的生活质量。激素替代治疗(MHT)可以有效改善女性绝经期的相关症状,是目前临床上主要的治疗方式。但许多研究认为,MHT可能增加乳腺癌等疾病的发生风险,导致MHT对绝经期女性的使用一度停滞不前。以科学辨证的态度正视MHT的利弊对于女性绝经期的管理至关重要。本文就女性绝经期MHT目前存在的争议和共识进行综述。

Menopause is an important and long transition in a woman's life,and causes a series of clinical symptoms such as osteoporosis,which seriously impairs a woman's quality of life during this special period.Menopause hormone therapy(MHT)can effectively improve the symptoms associated with menopause in women and is currently the main treatment modality.However,many studies have concluded that MHT may increase the risk of developing diseases such as breast cancer,leading to a stagnation in the use of MHT for menopausal women.A scientifically discriminating approach that confronts the pros and cons of MHT is essential for the management of women during menopause.This article reviews the current controversies and consensus on MHT for women during menopause.