甘氨酸茶碱钠缓释片治疗支气管哮喘的效果

Effect of Theophylline Sodium Glycinate Sustained Release Tablets in the treatment of bronchial asthma

目的观察甘氨酸茶碱钠缓释片治疗支气管哮喘的效果及对氧化应激指标的影响。方法选择2018年11月至2020年9月国药同煤总医院收治的105例支气管哮喘患者为研究对象,按随机数字表法将其分为对照组52例和观察组53例。对照组予常规治疗,观察组加用甘氨酸茶碱钠缓释片,3个月为1个疗程。比较两组临床疗效,主要临床症状(咳嗽、喘憋、肺部湿啰音、肺部哮鸣音)消失时间,肺功能[第1秒用力呼气容积(FEV_(1))、第1秒用力呼气量占所有呼气量的比例(FEV_(1)/FVC)、呼气峰流速(PEF)],氧化应激指标[丙二醛(MDA)、过氧化脂质(LPO)、还原型谷胱甘肽(GSH)含量及超氧化物歧化酶(SOD)],记录不良反应等。结果两组总有效率比较,差异无统计学意义(P>0.05)。观察组咳嗽、喘憋、肺部湿啰音、肺部哮鸣音消失时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,两组FEV_(1)、FEV_(1)/FVC、PEF、GSH、SOD较治疗前升高,MDA、LPO降低(P<0.05);且观察组FEV_(1)、FEV_(1)/FVC、PEF、SOD高于对照组,MDA、LPO低于对照组,差异有统计学意义(P<0.05),两组GSH比较,差异无统计学意义(P>0.05)。两组均无明显不良反应发生。结论甘氨酸茶碱钠缓释片联合常规方案治疗支气管哮喘安全有效,且可降低氧化应激损伤。

Objective To observe the clinical efficacy of Theophylline Sodium Glycinate Sustained Release Tablets in the treatment of bronchial asthma and the impacts on oxidative stress.Methods A total of 105 cases with bronchial asthma admitted to Sinopharm Tongmei General Hospital from November 2018 to September 2020 were selected as the research objects,and they were divided into control group(52 cases)and study group(53 cases)according to the random number table method.The control group received conventional treatment,the study group received Theophylline Sodium Glycinate Sustained Release Tablets additionally,the treatment course was three months.The clinical efficacy,disappearing time of main clinical symptoms(cough,breathe heavily,lung moist rale,and lung wheezing),pulmonary function(forced expiratory volume in one second[FEV_(1)],FEV_(1)/FVC,peak expiratory flow[PEF]),and oxidative stress indexes(malondialdehyde[MDA],lipid peroxide[LPO],reduced glutathione[GSH],and superoxide dismutase[SOD])were compared,the adverse reactions were recorded.Results There was no significant difference in the total effective rate between the two groups(P>0.05).The disappearance time of cough,breathe heavily,lung moist rale,and lung wheezing in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,FEV_(1),FEV_(1)/FVC,PEF,GSH,and SOD increased,while MDA and LPO decreased compared with before treatment in two groups(P<0.05).FEV_(1),FEV_(1)/FVC,PEF,and SOD in the observation group were higher than those in the control group,while MDA and LPO were lower than those in the control group,the differences were statistically significant(P<0.05),while GSH between the two groups showed no significant difference(P>0.05).There were no obvious adverse reactions in both groups.Conclusion Theophylline Sodium Glycinate Sustained Release Tablets combined with conventional treatment are effective and safe for patients with bronchial asthma,and could decrease the oxidative stress injury.