血栓通胶囊联合阿托伐他汀与阿司匹林在脑梗死二级预防中的应用效果

Evaluation of the Effect of Xueshuantong Capsule Combined with Atorvastatin and Aspirin in the Secondary Prevention of Cerebral Infarction

目的:探究与分析血栓通胶囊联合阿托伐他汀和阿司匹林在脑梗死二级预防中的应用效果。方法:选取2018年5月-2020年5月哈尔滨市第四医院收治的120例脑梗死患者,采取随机数字表法将其分为对照组与观察组,每组60例。对照组给予阿托伐他汀+阿司匹林治疗,同时给予二级预防措施,观察组在对照组基础上加用血栓通胶囊。比较两组治疗前后血脂水平[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)]、神经功能缺损评分(NIHSS)、颈动脉内膜中层厚度(IMT)、血清超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)和肿瘤坏死因子-α(TNF-α)水平,同时比较两组治疗期间不良反应发生情况。结果:治疗后,两组TC、TG、LDL-C水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组HDL-C水平均高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组NHISS评分低于对照组,差异有统计学意义(P<0.05)。治疗后,两组IMT值比较,差异无统计学意义(P>0.05)。治疗后,观察组hs-CRP、MMP-9及TNF-α水平均低于对照组,差异均有统计学意义(P<0.05)。对照组出现1例恶心、心慌,观察组出现1例咽干,均未经过任何特殊处理即自行缓解。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血栓通胶囊联合阿托伐他汀和阿司匹林应用于脑梗死二级预防中可有效地调节血脂指标,改善神经功能缺损情况,促进稳定并消退斑块,改善炎症反应,且治疗期间无明显不良反应,安全性较高。

Objective:To explore and analyze the effect of Xueshuantong Capsules combined with Atorvastatin and Aspirin in the secondary prevention of cerebral infarction.Method:A total of 120 patients with cerebral infarction admitted to Harbin Fourth Hospital from May 2018 to May 2020 were selected,they were divided into control group and observation group according to random number table,60 cases in each group.The control group was given Atorvastatin+Aspirin treatment,at the same time,secondary prevention measures were given.The observation group was given Xueshuantong Capsules on the basis of the control group.The blood lipid levels[total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglyceride(TG)],neurological deficit score(NIHSS),carotid artery intima-media thickness(IMT),hypersensitive C-reactive protein(hs-CRP),matrix metalloproteinase-9(MMP-9)and tumor necrosis factor-α(TNF-α)levels before and after treatment were compared between two groups,and adverse reactions during treatment was compared between two groups.Result:After treatment,the levels of TC,TG,LDL-C in both groups were lower than those before treatment,those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,HDL-C levels in both groups were higher than those before treatment,and that in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,NHISS score in the observation group were lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,there was no significant differences in IMT between two groups(P>0.05).After treatment,the levels of hs-CRP,MMP-9 and TNF-αin the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Nausea and palpitation occurred in 1 case in the control group and dry pharynx occurred in 1 case in the observation group,which were relieved spontaneously without any special treatment.There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Xueshuantong Capsules combined with Atorvastatin and Aspirin in the secondary prevention of cerebral infarction can effectively regulate blood lipids,improve neurological deficits,promote stabilization and subsidence of plaques,improve inflammatory reactions,and there are no obvious adverse reactions during the treatment,with high safety.