甲泼尼龙序贯泼尼松联合双嘧达莫治疗小儿肾病综合征的效果及对肾功能、凝血功能的影响

Effect of Methylprednisolone Sequential Prednisone Combined with Dipyridamole in the Treatment of Pediatric Nephrotic Syndrome and Its Influence on Renal and Coagulation Function

目的:探讨甲泼尼龙序贯泼尼松联合双嘧达莫治疗小儿肾病综合征(NS)的效果及对肾功能、凝血功能的影响。方法:回顾性分析2018年4月-2020年6月泉州市儿童医院收治的80例小儿NS患者的临床资料,按照治疗方案分成对照组和观察组,每组40例。对照组采用甲泼尼龙序贯泼尼松治疗,观察组在对照组的基础上加用双嘧达莫治疗。比较两组疗效、治疗前后的肾功能指标[血肌酐(Scr)、尿素氮(BUN)]和凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]。结果:观察组总有效率为90.00%,高于对照组的67.50%,差异有统计学意义(P<0.05)。治疗前,两组Scr、BUN、APTT、PT比较,差异均无统计学意义(P>0.05);治疗后,观察组Scr、BUN均低于对照组,APTT、PT均长于对照组,差异均有统计学意义(P<0.05)。结论:甲泼尼龙序贯泼尼松联合双嘧达莫治疗小儿NS的效果理想,能有效改善患者的肾功能、凝血功能,适合作为小儿NS的治疗用药。

Objective:To investigate the effect of Methylprednisolone sequential Prednisone Combined with Dipyridamole in the treatment of pediatric nephrotic syndrome and its influence on renal and coagulation function.Method:The clinical data of 80 pediatric NS patients admitted to Quanzhou Children’s Hospital from April 2018 to June 2020 were retrospectively analyzed,and they were divided into control group and observation group according to treatment plan,40 cases in each group.The control group was treated with Methylprednisolone sequential Prednisone,and the observation group was treated with Dipyridamole on the basis of the control group.The efficacy,renal function indexes[serum creatinine (Scr),urea nitrogen (BUN)]and coagulation function[prothrombin time (PT),activated partial thrombin time (APTT)]before and after treatment were compared between two groups.Result:The total effective rate in observation group was 90.00%,which was higher than 67.50% in control group,the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in Scr,BUN,APTT and PT between two groups (P>0.05);after treatment,Scr and BUN in the observation group were lower than those in the control group,APTT and PT in the observation group were longer than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Methylprednisolone sequential Prednisone combined with Dipyridamole is effective in the treatment of pediatric NS.It can effectively improve the renal function and blood coagulation function of patients,and is suitable for the treatment of pediatric NS.