盐酸米诺环素软膏与替硝唑缓释药膜对牙周炎的疗效

The Effect of Minocycline Hydrochloride Ointment and Tinidazole Sustained-release Film on Periodontitis

目的:探究盐酸米诺环素软膏与替硝唑缓释药膜在牙周炎治疗中的效果及不良反应发生状况。方法:在荆州市第二人民医院2019年1月-2020年1月诊治的牙周炎患者中选出144例为对象,以随机数字表法分组,米诺环素组(n=72)给予盐酸米诺环素软膏治疗,替硝唑组(n=72)应用替硝唑缓释药膜治疗,对比两组的总有效率、不良反应发生率等。结果:治疗4周后,米诺环素组的总有效率高于替硝唑组(P<0.05);且米诺环素组治疗后的龈沟液肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、前列腺素E;(PGE;)水平均低于替硝唑组(P<0.05);两组的丘疹、用药胀痛感和食欲不振的发生率及总不良反应发生率比较差异均无统计学意义(P>0.05),两组均为轻度不良反应。结论:在牙周炎的药物治疗中,盐酸米诺环素软膏与替硝唑缓释药膜的局部用药的安全性均较高,其中盐酸米诺环素软膏的疗效更确切,值得推广。

Objective:To explore the effects of Minocycline Hydrochloride Ointment and Tinidazole Sustained-release Film in the treatment of periodontitis and the occurrence of adverse reactions.Method:A total of 144 patients with periodontitis diagnosed and treated in the Second Hospital of Jingzhou from January 2019 to January 2020 were selected as subjects,and grouped by random number table,the Minocycline group (n=72) was treated with Minocycline Hydrochloride Ointment,and the Tinidazole group (n=72) was treated with Tinidazole Sustained-release Film.The total effective rate and the incidence of adverse reactions were compared between the two groups.Result:After 4 weeks of treatment,the total effective rate of the Minocycline group was higher than that of the Tinidazole group (P<0.05);and the gingival crevicular fluid TNF-α,hs-CRP,IL-6,PGE_(2)levels in the Minocycline group after treatment were lower than the Tinidazole group (P<0.05);there were no significant differences in the incidence of papules,medication pain,loss of appetite,and overall adverse reactions between the two groups (P>0.05).There were mild adverse reactions.Conclusion:In the drug treatment of periodontitis,the safety of topical Minocycline Hydrochloride Ointment and Tinidazole Sustained-release Film is relatively high,and the curative effect of Minocycline Hydrochloride Ointment is more accurate and worthy of promotion.