注射用重组人白细胞介素-2联合2HREZ/4HRE方案治疗初治涂阳肺结核患者的效果观察

Effect of Recombinant Human Interleukin-2 for Injection Combined with 2HREZ/4HRE Regimen in the Treatment of Primary Smear Positive Pulmonary Tuberculosis Patients

目的:分析注射用重组人白细胞介素-2(rIL-2)联合2HREZ/4HRE方案治疗初治涂阳肺结核的效果及安全性。方法:选取2019年8月-2020年8月新疆生产建设兵团第一师阿拉尔医院收治的50例初治涂阳肺结核患者,随机数字表法将其分为常规组和研究组,每组25例。常规组给予2HREZ/4HRE方案治疗,研究组给予rIL-2^(+)2HREZ/4HRE方案治疗。比较两组疗效、药物不良反应发生情况及治疗前、治疗后1个月T淋巴细胞亚群(CD3^(+)、CD8^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平。结果:研究组总有效率为96.00%,高于常规组的68.00%,差异有统计学意义(P<0.05)。治疗后1个月,研究组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于常规组,CD8^(+)低于常规组,差异均有统计学意义(P<0.05)。两组胃肠道反应、肾功能损害、肝功能损害、高尿酸血症、皮疹、血液系统异常发生率比较,差异均无统计学意义(P>0.05)。研究组皮肤硬结、发热发生率均高于常规组,差异均有统计学意义(P<0.05)。结论:rIL-2联合2HREZ/4HRE方案治疗初治涂阳肺结核效果确切,能有效改善人体免疫功能,且药物耐受性良好.

Objective:To analyze the efficacy and safety of Recombinant Human Interleukin-2 (rIL-2) for Injection combined with 2HREZ/4HRE regimen in the treatment of primary smear positive pulmonary tuberculosis patients.Method:A total of 50 primary smear positive pulmonary tuberculosis patients in Alar Hospital of the 1st Division of Production and Construction Corps,Xinjiang from August 2019 to August 2020 were selected,and they were divided into conventional group and study group according to random number table method,25 cases in each group.The conventional group was given 2HREZ/4HRE regimen,and the study group was given rIL-2 +2HREZ/4HRE regimen.The therapeutic effect,the incidence of adverse drug reactions,and the changes of T lymphocyte subsets (CD3^(+),CD8^(+),CD4^(+),CD4^(+)/CD8^(+)) before and 1 month after treatment were compared between two groups.Result:The total effective rate of the study group was 96.00%,which was higher than 68.00% of the conventional group,the difference was statistically significant (P<0.05).1 month after treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)of the study group were higher than those of the conventional group,CD8^(+)of the study group was lower than that of the conventional group,the differences were statistically significant (P<0.05).There were no significant differences in the incidence of gastrointestinal reaction,renal function impairment,liver function impairment,hyperuricemia,rash and abnormal blood system between two groups (P>0.05).The incidence of skin hardening and fever of the study group were higher than those of the conventional group,the differences were statistically significant (P<0.05).Conclusion:rIL-2 combined with 2HREZ/4HRE is effective in the treatment of primary smear positive pulmonary tuberculosis,which can effectively improve human immune function and has good drug tolerance.