具核梭形杆菌与结直肠癌患者预后相关性的meta分析

Meta-Analysis of the Correlation Between Fusobacterium Nucleatum and the Prognosis of Patients with Colorectal Cancer

目的评估具核梭形杆菌在预测结直肠癌患者预后中的作用。方法检索Pubmed、Embase及Web of Science数据库,收集研究具核梭形杆菌对结直肠癌患者预后评估价值的文献,使用Review Manager 5.3中的倒方差法对总生存时间(OS)进行meta分析。结果共纳入8篇文献,总计2022例结直肠癌患者。meta分析结果提示,具核梭形杆菌高丰度组OS与具核梭形杆菌低丰度组相比,差异有统计学意义(HR=1.45,95%CI:1.18~1.79,I^(2)=20%,P<0.05)。结论具核梭形杆菌高丰度结直肠癌患者与具核梭形杆菌低丰度者相比,预后较差。具核梭形杆菌可以作为预测结直肠癌患者预后的指标。

Objective To evaluate the role of Fusobacterium nucleatum in predicting the prognosis of patients with colorectal cancer.Methods The Pubmed,Embase,and Web of Science databases were searched,and the literature on the prognostic evaluation of Fusobacterium nucleatum in patients with colorectal cancer was collected.The overall survival(OS)was meta-analyzed using the inverse variance method in Review Manager 5.3.Results A total of 8 articles containing 2022 patients with colorectal cancer were included.The meta-analysis indicated that the OS of the high-abundance Fusobacterium nucleatum group was statistically different from that of the low-abundance Fusobacterium nucleatum group(HR=1.45,95%CI:1.18-1.79,I^(2)=20%,P<0.05).Conclusion The prognosis of colorectal cancer patients with high abundance of Fusobacterium nucleatum is worse than that of patients with low abundance of Fusobacterium nucleatum.Fusobacterium nucleatum could be used as an indicator to predict the prognosis of patients with colorectal cancer.