乙肝肝硬化患者门静脉血栓形成的相关因素分析

Related Factors of Portal Vein Thrombosis Formation in Hepatitis B Cirrhosis Patients

目的分析乙肝肝硬化患者门静脉血栓(PVT)形成的影响因素。方法选取2018年7月至2021年6月新乡市传染病医院肝病科350例乙肝肝硬化患者作为研究对象,统计所有患者PVT形成情况,由研究者设计基线资料调查问卷,询问并记录患者基线资料,检测研究所需的实验室指标并比较,将可能的影响因素纳入,经logistic回归分析检验,找出乙肝肝硬化患者PVT形成的影响因素。结果350例乙肝肝硬化患者中PVT形成31例,发生率为8.86%(31/350);发生组合并糖尿病占比高于未发生组,发生组门静脉血流速度、白蛋白(ALB)水平比未发生组低,发生组血小板计数(PLT)比未发生组高,差异有统计学意义(P<0.05);logistic回归分析检验结果显示,合并糖尿病、PLT水平高是乙肝肝硬化患者PVT形成的危险因素(OR>1,P<0.05);门静脉血流速度快、ALB水平高是其保护因素(OR<1,P<0.05)。结论乙肝肝硬化患者PVT形成的影响因素可能为合并糖尿病、PLT水平高、门静脉血流速度快、ALB水平高。

Objective To analyze the influencing factors of portal vein thrombosis(PVT)in patients with hepatitis B cirrhosis.Methods A total of 350 patients with hepatitis B cirrhosis in Xinxiang Infectious Disease Hospital from July 2018 to June 2021 were selected as the research subjects.The formation of PVT in all patients was counted,and the baseline data questionnaire was designed by the researcher,then asked and recorded baseline data of patients.Tested and compared the laboratory indicators required for the study,then included possible influencing factors.By logistic regression analysis,the influencing factors of PVT formation in patients with hepatitis B cirrhosis were found out.Results Among the 350 patients with hepatitis B cirrhosis,31 cases were formed by PVT,the incidence rate was 8.86%(31/350).Compared with the non occurrence group,the proportion of combined diabetes mellitus was higher,the portal venous blood flow velocity and albumin(ALB)level were lower and the platelet count(PLT)was higher than in the occurrence group(P<0.05).Through logistic regression analysis,the results showed that,combined diabetes mellitus and high level of PLT were risk factors for PVT formation in patients with hepatitis B cirrhosis(OR>1,P<0.05);fast portal vein blood flow velocity and high ALB level were its protective factors(OR<1,P<0.05).Conclusion The influencing factors of PVT formation in hepatitis B cirrhosis patients may be combined diabetes mellitus,high PLT level,fast portal blood flow velocity and high ALB level.