摘要
过氧化物酶体增殖物激活受体γ(Peroxisome Proliferators-activated Receptorγ,PPARγ)是调控炎症反应的关键物质之一,其通过减弱核因子Kappa B(Nuclear Factor-kappa B,NF-κB)、c-Jun氨基末端激酶(c-Jun N-terminal Kinase,JNK)活性,降低炎症因子含量从而缓解炎症反应,另一方面PPARγ与腺苷酸激活蛋白激酶(AMP-activated Protein Kinase,AMPK)互相抑制,共同维持动物正常机能。本文综述了PPARγ对动物炎症通路的调控作用,为其进一步研究和应用提供参考。
Peroxisome proliferators activated receptorγ(PPARγ)is one of the key substances in regulation of inflammatory response.On the one hand,PPARγcan reduce the content of inflammatory factors and alleviate the inflammatory response by attenuating the activity of nuclear factor-kappa B(NF-κB)and c-Jun N-terminal Kinase(JNK).On the other hand,it inhibits each other with AMP-activated protein kinase(AMPK)to maintain the normal function of animals.Therefore,this paper focuses on the regulatory role of PPARγon animal inflammatory pathway,in order to provide reference for the further application of PPARγ.
作者
李保锋
黎力之
谢芳
郭冬生
张海波
黄晓
廖晓鹏
关玮琨
LI Baofeng;LI Lizhi;XIE Fang;GUO Dongsheng;ZHANG Haibo;HUANG Xiao;LIAO Xiaopeng;GUAN Weikun(College of Life Science and Resources and Environment,Yichun University,Engineering Technology Research Center of Jiangxi Universities and Colleges for Selenium Agriculture,College of Continuing Education,Yichun University,Yichun Vocational and Technical College,Jiangxi Yichun 336000,China;Qingdao Animal Husbandry and Veterinary Institute,Shandong Qingdao 266000,China)
出处
《中国畜牧杂志》
CAS
北大核心
2022年第1期32-37,共6页
Chinese Journal of Animal Science
基金
国家地区科学基金(32060773)
江西省自然科学基金(20202BABL205010)
江西省教改课题(JXJG-20-15-20)
江西省现代农业产业技术体系建设专项资金资助(JXARS-14)
宜春学院教改课题(YCUJG-2019-30)
江西省教育厅项目(GJJ190848、GJJ201621)。
关键词
过氧化物酶体增殖物激活受体Γ
NF-кB信号通路
JNK信号通路
AMPK信号通路
炎症
Peroxisome proliferation-activated receptorγ
Nuclear factor-kappa B signaling pathway
c-Jun n-terminal kinase signaling pathway
AMP-activated protein kinase signaling pathway
Inflammation
