实验动物在评价天王补心丹防治失眠中的作用

Role of experimental animals in evaluating prevention and treatment of insomnia with Tianwang Buxin Dan

失眠作为常见的神经精神疾病,发病率逐年上升。天王补心丹是补心安神治疗失眠的经典中医方剂,临床应用广泛。对天王补心丹的药理作用评价与作用机制研究需以适当的动物模型为基础。本文对近10年相关文献进行汇总,针对多平台水环境模型、对氯苯丙氨酸(parachlorophenylalanine, PCPA)失眠模型、光照节律紊乱模型和中医证候复合模型的优缺点、造模方法、评价指标等特点进行阐述。探讨天王补心丹及组方单味药材改善睡眠的指标与中医证候的内在联系,为建立符合中医特点的失眠动物模型提供参考,为天王补心丹用于失眠治疗提供借鉴。

Insomnia is a common neuropsychiatric disease with increasing incidence in recent years. Tianwang Buxin Dan(TWBXD) is a traditional Chinese medicine(TCM) prescription to invigorate the heart and calm nerves for the treatment of insomnia, which is widely used in clinical practice. Investigation of the pharmacological effects and action mechanism of TWBXD is based on the establishment of proper animal models. This article summarizes relevant literature in the past 10 years with a focus on multiple insomnia animal models(platform over water, parachlorophenylalanine, light rhythm disturbance, and TCM syndrome) and their strengths and weaknesses, methodology, and evaluation properties. The sleep-improving effects of TWBXD and its signal herbs are associated with TCM syndrome to establish animal models that fit the characteristics of TCM syndrome and provide a reference for the clinical application of TWBXD.