张家口市4868例女性人乳头瘤病毒感染分析

Analysis of 4868 cases of female human papillomavirus infection in Zhangjiakou city

目的分析张家口地区女性感染高危型人乳头瘤病毒(HPV)的现况特点,为制定预防及筛查宫颈癌提供科学依据。方法选择2016年1月至2020年10月期间在张家口市第一医院自愿进行HPV分型检测的4868例女性为研究对象,采用PCR技术和杂交技术对其进行HPV分型检测。按照年龄、学历和感染类型等因素对研究对象进行分组,统计分析不同组间的感染情况及复发率。结果地区感染率最高的高危亚型为52型、16型、51型、58型、53型、56型和18型,以单一亚型感染为主;各年龄段患者总阳性检出率差异有统计学意义,在31~40岁年龄段检出率最高。单一感染类型的阳性检出率在31~40岁与51~60岁两个年龄组占比较高,31~40岁组与51~60岁组比较,差异有统计学意义(P<0.05)。双重感染类型的阳性检出率在41~50岁年龄组比例最高,组间比较,差异有统计学意义(P<0.05)。三重感染类型的阳性检出率在51~60岁年龄组比例最高,组间比较,差异无统计学意义(P>0.05)。不同学历患者总阳性检出率比较,差异有统计学意义(P<0.05),初中学历受检者阳性率最高为20.2%。复发感染中,小学学历的人群感染复发率最高为68.1%,并且与其他组比较,差异有统计学意义(χ^(2)=128.59,P<0.05)。三重感染的复发率最高为88%,并且与其他组比较,差异有统计学意义(χ^(2)=129.40,P<0.05)。结论本地区HPV感染亚型分布与其他地区存在显著性差异,其感染水平与年龄、学历等因素呈现显著的相关性。

Objective To analyze the current situation and characteristics of women infected with high-risk human papillomavirus(HPV)in this region,to provide scientific basis for the prevention and screening of cervical cancer.Methods A total of 4868 women who volunteered for HPV genotyping in Zhangjiakou First Hospital from January 2016 to October 2020 were selected as the research subjects.PCR technology and hybridization technology were used for HPV genotyping.The subjects were grouped according to age,educational background and infection type,and the infection status and recurrence rate among different groups were statistically analyzed.Results The high-risk subtypes with the highest infection rate in the region were Type 52,Type 16,Type 51,Type 58,Type 53,Type 56,and Type 18,the single subtype infection was dominant.There were statistical differences in the total positive detection rate of patients in all age groups,and the highest detection rate was in the age group of 31 to 40 years old.The positive detection rates of a single infection type were higher in the 31~40 years old group and the 51~60 years old group,The difference between31~40 years old group and 51~60 years old group was statistically significant(P<0.05).The positive detection rate of dual infection was the highest in the 41-50 years old age group,and there was statistical difference among groups(P<0.05).The positive detection rate of triple infection was the highest in the 51~60 age group,but there was no statistical difference among groups.There was statistical difference in the total positive detection rate with different academic qualifications(P<0.05),and the highest positive rate with junior high school education was 20.2%.Among the recurrent infections,the highest recurrent rate of infection was 68.1%in the population with primary school education,and the difference was statistically significant compared with other groups(χ^(2)=128.59,P<0.05).The highest recurrence rate of triple infection was 88%,and the difference was statistically significant compared with other groups(χ^(2)=129.40,P<0.05).Conclusion The distribution of HPV infection subtypes in Zhangjiakou is significantly different from those in other regions,and the infection level shows a significant correlation with age and educational background.