三明市219例0〜1岁婴儿药品不良反应报告分析

Analysis of 219 Cases of Adverse Drug Reactions in Infants Aged 0-1 years in Sanming City

目的探讨0~1岁婴儿发生药品不良反应的特点及规律,为医生临床安全用药提供指导。方法对我市2016年~2020年国家药品不良反应监测系统中收集的0-1岁婴儿药品不良反应进行回顾性分析。结果0~1岁婴儿通过静脉滴注发生药品不良反应机率较高;发生药品不良反应的男女婴比例为1.5:1;主要以抗生素类为主,出现频率最高的药物是阿莫西林克拉维酸钾制剂;经分析新的/严重的比例为16.4%;主要的临床表现以皮肤及其附件损害为主。结论应重视婴儿药品不良反应监测,保证婴儿用药安全合理。

OBJECTIVE To explore the characteristics and rules of adverse drug reactions in 0-1-year-old infants,so as to provide guidance for doctors to use drugs safely.METHODS The adverse drug reactions of 0-1-year-old infants collected in the national adverse drug reaction monitoring system in our city from 2016 to 2020 were analyzed retrospectively.RESULTS The incidence of adverse drug reactions in 0-1-year-old infants was high;The proportion of male and female infants with ADR was 1.5:1;mainly antibiotics.The most frequent drug was amoxicillin clavulanate potassium preparation;After analysis,the new/serious proportion was 16.4%;The main clinical manifestation was skin and its accessories damage.CONCLUSION We should pay attention to the monitoring of adverse drug reactions in infants to ensure the safety and rationality of drug use in infants.