血清骨性蛋白与帕金森病患者病情严重程度及认知障碍的相关性研究

Correlation between serum bone protein and disease severity and cognitive impairment in patients with Parkinson’s disease

目的探讨帕金森病(Parkinson’s disease,PD)患者血清骨桥蛋白(Osteopontin,OPN)、骨保护素(Osteoprotegerin,OPG)及骨钙素(Osteocalcin,OCN)与病情严重程度及认知障碍的关系。方法纳入52例PD患者(PD组),进行H-Y分期、UPDRSⅢ以及MoCA评分,并且根据MoCA评分将PD分为认知正常组20例,认知障碍组32例。纳入同期36例健康体检者(对照组),检测各组血清OPN、OPG以及OCN水平,进行统计分析。结果PD组血清OPN、OCN水平高于对照组(P<0.05),OPG低于对照组(P<0.05);PD认知障碍组血清OPN高于PD认知正常组(P<0.05);Spearman相关分析显示,PD患者血清OPN、OCN与H-Y分期及UPDRSⅢ评分呈正相关(P<0.05),血清OPN与MoCA评分、注意力、计算力以及抽象思维呈负相关(P<0.05),血清OCN水平与延迟回忆呈正相关(P<0.05);Logistic回归分析提示OPN是PD认知障碍的危险因素。结论血清OPN、OPG及OCN与PD发病有关,血清OPN、OCN可进一步评估PD患者病情,并且与认知障碍相关。

Objective To investigate the relationship between serum Osteopontin(OPN),Osteoprotegerin(OPG)and Osteocalcin(OCN)in patients with Parkinson’s disease(PD)and the severity of the disease and cognitive impairment Relationship.Methods Fifty-two PD patients(PD group)were included,and H-Y staging,UPDRSⅢ,and MoCA score were performed.According to the MoCA score,PD was divided into a cognitively normal group of 20 cases and a cognitively impaired group of 32 cases.In the same period,36 healthy subjects(control group)were included,and the serum OPN,OPG and OCN levels in each group were detected for statistical analysis.Results The serum OPN and OCN levels in the PD group were higher than those in the control group(P<0.05),and OPG was lower than the control group(P<0.05);serum OPN was higher in PD cognitive impairment group than in normal PD cognitive group(P<0.05);Results from spearman correlation analysis showed that serum OPN and OCN of PD patients were positively correlated with H-Y staging and UPDRSⅢscore(P<0.05).OPN was negatively correlated with MoCA score,attention,calculation ability and abstract thinking(P<0.05),and serum OCN level was positively correlated with delayed recall(P<0.05);Logistic regression analysis suggests that OPN is a risk factor for PD cognitive impairment.Conclusion Serum OPN,OPG and OCN are related to the pathogenesis of PD.Serum OPN and OCN can further evaluate the condition of PD patients and are related to cognitive impairment.