钆塞酸二钠增强磁共振成像在肝细胞癌生物学行为评估中的应用进展

Research progress of Gd-EOB-DTPA-enhanced magnetic resonance imaging in the evaluation of biological behavior of hepatocellular carcinoma

肝细胞癌是肝脏最常见的原发性恶性肿瘤,是癌症相关死亡的第三大原因。钆塞酸二钠(gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid,Gd-EOB-DTPA)为目前常用的新型肝脏特异性对比剂,其诊断小肝细胞癌的敏感度和特异度均可高于90%。肝细胞癌的早期诊断可使患者临床获益,但肝细胞癌作为高度异质性肿瘤,其生物学行为也是影响预后的关键因素。Gd-EOB-DTPA增强磁共振成像(Gd-EOB-DTPA-enhanced magnetic resonance imaging,EOB-MRI)在识别肝细胞癌分子分型、评估免疫微环境、预测微血管侵犯以及术后复发等方面均能提供相关信息。该文即对EOB-MRI在肝细胞癌生物学行为评估中的应用进展作一综述,以期为肝细胞癌的诊断和治疗提供参考。

Hepatocellular carcinoma is the most common primary malignant tumor of liver tumors and ranked as the third leading cause of cancer death. Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA) is a new hepatocyte-specific contrast agent commonly used at present. Its sensitivity and specificity for the diagnosis of small hepatocellular carcinoma can both be over 90%. Early diagnosis of hepatocellular carcinoma can benefit patients clinically, but as hepatocellular carcinoma is a highly heterogeneous tumor, the tumor biological behavior is also a key factor affecting the prognosis. Gd-EOB-DTPA-enhanced magnetic resonance imaging(EOB-MRI) can provide relevant information about identification of molecular typing, evaluation of immune microenvironment, and prediction of microvascular invasion and postoperative recurrence in hepatocellular carcinoma. This article reviews the research progress of EOB-MRI in the evaluation of biological behavior of hepatocellular carcinoma to provide reference for the diagnosis and treatment of hepatocellular carcinoma.