达格列净对T2DM合并慢性心力衰竭患者血糖、血脂及左心室舒张功能的影响

Effects of Dapagliflozin on Blood Glucose, Blood Lipids and Left Ventricular Diastolic Function in Patients with T2DM Combined with Chronic Heart Failure

目的:研究达格列净对T2DM合并慢性心力衰竭(CHF)患者血糖、血脂及左心室舒张功能的影响。方法:选取2020年1月-2021年1月本院收治的T2DM合并CHF患者80例,使用随机数字表法将其分为对照组(n=40)和研究组(n=40)。两组均给予抗心力衰竭治疗,对照组给予常规降糖药物治疗,研究组在对照组基础上给予达格列治疗。观察两组治疗前后血糖水平、血脂水平、左心室舒张功能。结果:治疗后,两组FBG、2 h PBG、HbA1c水平较治疗前均降低(P<0.05),且研究组均低于对照组(P<0.05)。治疗后,两组LDL-C、TG水平较治疗前均降低(P<0.05),且研究组均低于对照组(P<0.05);治疗后,两组HDL-C水平较治疗前均升高(P<0.05),且研究组高于对照组(P<0.05)。治疗后,两组LAVI、LVML、E/e’较治疗前均降低(P<0.05),且研究组均低于对照组(P<0.05)。结论:达格列净应用于T2DM合并CHF患者可纠正血糖紊乱,改善血脂水平,促进左心室舒张功能恢复。

Objective:To study the effects of Dapagliflozin on blood glucose,blood lipids and left ventricular diastolic function in patients with T2DM combined with chronic heart failure (CHF).Method:A total of 80 patients with T2DM combined with CHF admitted to our hospital from January 2020 to January 2021 were selected and divided into the control group (n=40) and the study group (n=40) according to the random number table method.Both groups were given anti-heart failure,the control group was treated with conventional hypoglycemic drugs,and the study group was treated with Dapagliflozin on the basis of the control group.The blood glucose level,blood lipid level and left ventricular diastolic function of two groups before and after treatment were compared.Result:After treatment,the levels of FBG,2 h PBG,and HbA1c of two groups were lower than those before treatment (P<0.05),and the study group were lower than those of the control group (P<0.05).After treatment,the levels of LDL-C and TG of two groups were lower than those before treatment (P<0.05),and the study group were lower than those of the control group (P<0.05);after treatment,the levels of HDL-C of two groups were higher than those before treatment (P<0.05),and the study group was higher than that of the control group (P<0.05).After treatment,the LAVI,LVML,E/e’ of two groups were lower than those before treatment (P<0.05),and the study group were lower than those of the control group (P<0.05).Conclusion:The application of Dapagliflozin in patients with T2DM combined with CHF can correct blood glucose disorders,improve blood lipid levels and promote the recovery of left ventricular diastolic function.