IL-33在非感染性肺部疾病中的研究进展

Research Progress of IL-33 in Non-infectious Lung Diseases

白介素-33(IL-33)作为IL-1家族中的一种细胞因子,它可以在组织受到损伤时,与特异性受体肿瘤发生抑制蛋白2(ST2)相结合,进而在免疫反应中发挥促炎及抗炎作用。近年来,IL-33的免疫功能已成为许多疾病的研究焦点,尤其在慢性阻塞性肺疾病、哮喘、特发性肺纤维化、阻塞性睡眠呼吸暂停综合征、肺癌等疾病中,均可发现IL-33水平显著升高,但其具体作用机制却不完全一致。因此,本研究通过总结IL-33对常见非感染性肺部疾病的相关影响,为IL-33在肺部疾病中的靶向治疗提供临床依据。

Interleukin-33 (IL-33) as a cytokine in the IL-1 family,can bind to the suppression of tumorigenicity 2 (ST2) when the tissue is damaged,and then play a pro-inflammatory and anti-inflammatory role in the immune response.In recent years,the immune function of IL-33 has become the research focus of many diseases,especially in chronic obstructive pulmonary disease,asthma,idiopathic pulmonary fibrosis,obstructive sleep apnea syndrome,lung cancer and other diseases,it can be found that the level of IL-33 is significantly increased,but its specific mechanism is not completely consistent.Therefore,this study summarizes the effects of IL-33 on common non-infectious lung diseases in order to provide clinical basis for the targeted treatment of IL-33 in lung diseases.