双能X线骨密度仪与血清B-ALP、BGP、TRACP5b在骨质疏松症中的应用价值

Application Value of Dual Energy X-ray Bone Absorptiometry and Serum B-ALP,BGP and TRACP5b in Osteoporosis

目的:分析双能X线骨密度仪与血清骨特异性碱性磷酸酶(B-ALP)、骨钙素(BGP)、抗酒石酸酸性磷酸酶5b(TRACP5b)在骨质疏松症中的应用价值。方法:选择泰安市中医二院2018年1月-2020年6月诊治的骨质疏松症女性患者68例,将其纳入观察组。另选取同期健康体检的女性68例,将其纳入对照组。采用双能X线骨密度仪检测并比较两组骨密度与骨矿含量。比较两组血清B-ALP、BGP、TRACP5b水平,并分析其对骨质疏松症的预测价值。根据双能X线骨密度仪检测结果将观察组进行骨质疏松症分级,比较不同病情分级患者上述各指标。结果:观察组骨密度和骨矿含量均低于对照组(P<0.05)。观察组血清B-ALP、TRACP5b水平均高于对照组,BGP水平低于对照组(P<0.05)。B-ALP、BGP、TRACP5b预测骨质疏松症的AUC分别为0.871、0.726和0.735。不同骨质疏松症分级患者骨密度和骨矿含量比较,差异均有统计学意义(P<0.05),分级越高者骨密度和骨矿含量越低。不同骨质疏松症分级患者血清B-ALP、BGP、TRACP5b水平比较,差异均有统计学意义(P<0.05),分级越高者血清B-ALP和TRACP5b水平越高,BGP水平越低。结论:双能X线骨密度仪可明确骨质情况,进行病情分级。血清B-ALP、BGP、TRACP5b均对骨质疏松症具有一定的预测价值,且其变化趋势与病情分级有关。两者结合应用有利于提升对临床诊治的参考价值。

Objective:To analyze the application value of dual energy X-ray bone absorptiometry and serum bone-specific alkaline phosphatase(B-ALP),bone gla protein(BGP)and tartrate resistant acid phosphatase-5b(TRACP5b)in osteoporosis.Method:Sixty-eight female patients with osteoporosis diagnosed and treated in the Second Traditional Chinese Medicine Hospital of Taian from January 2018 to June 2020 were selected and included in the observation group.In addition,68 healthy female patients were included in the control group.The bone mineral density and bone mineral content of the two groups were detected and compared by dual energy X-ray bone absorptiometry.Serum B-ALP,BGP and TRACP5b levels were compared between the two groups,and their predictive value for osteoporosis was analyzed.According to the results of dual energy X-ray bone absorptiometry,the observation group was graded for osteoporosis,and the above indicators of patients with different disease grades were compared.Result:The bone mineral density and bone mineral content of observation group were lower than those of control group(P<0.05).The levels of serum B-ALP and TRACP5b of observation group were higher than those of control group,the level of BGP was lower than that of control group(P<0.05).The AUC of B-ALP,BGP and TRACP5b in predicting osteoporosis was 0.871,0.726 and 0.735,respectively.There were statistically significant differences in bone mineral density and bone mineral content among patients with different osteoporosis grades(P<0.05),and the higher the grade,the lower the BMD and bone mineral content.There were statistically significant differences in serum B-ALP,BGP and TRACP5b levels among patients with different osteoporosis grades(P<0.05),and the higher the grade,the higher the serum B-ALP and TRACP5b levels,the lower the BGP level.Conclusion:Dual energy X-ray bone absorptiometry can determine the condition of bone and grade the disease.Serum B-ALP,BGP and TRACP5b have certain predictive value for osteoporosis,and the change trend is related to the disease grade.The combination of the two can improve the reference value of clinical diagnosis and treatment.