复合维生素联合阿司匹林预防妊娠期高血压患者子痫前期的效果及对分娩结局的影响

Effect of Compound Vitamin Combined with Aspirin on Prevention of Preeclampsia in Gestational Hypertension Patients and Its Influence on Delivery Outcome

目的:探究复合维生素联合阿司匹林对妊娠期高血压患者子痫前期的防治效果及对分娩结局的影响。方法:选取2019年10月-2020年12月广宁县人民医院产科门诊就诊并符合研究标准的妊娠期高血压患者126例。根据随机数表法将其分为两组,试验组(62例)采用复合维生素联合阿司匹林治疗,对照组(64例)单独使用阿司匹林治疗。对比两组凝血功能、妊娠期并发症、围生期不良事件发生率及新生儿一般资料。结果:治疗前,两组纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)对比差异无统计学意义(P>0.05),妊娠结束时试验组FIB低于对照组,APTT长于对照组,差异有统计学意义(P<0.05)。试验组子痫前期发生率低于对照组(8.1% vs 21.9%,P<0.05),子痫发生率(1.6%)与对照组(10.9%)比较差异无统计学意义(P>0.05);试验组新生儿窒息、早产发生率均明显低于对照组(6.5% vs 23.4%,4.8% vs 18.8%,P<0.05),产后大出血、围生期死亡率(3.2%、0)与对照组(7.8%、4.7%)比较差异无统计学意义(P>0.05);试验组新生儿出生胎龄、出生体重、出生身长、出生头围,出生后1 min Apgar评分均优于对照组(P<0.05),胎儿宫内发育迟缓发生率低于对照组(1.6% vs 14.8%,P<0.05)。结论:复合维生素联合阿司匹林有助于改善妊娠期高血压患者的血液高凝状态,可以降低子痫前期的发病率,减少围生期不良事件发生,改善胎儿宫内发育情况。

Objective:To explore the effect of Compound Vitamin combined with Aspirin on the prevention and treatment of preeclampsia in patients with gestational hypertension and its impact on the delivery outcome.Method:A total of 126 patients with gestational hypertension who met the study criteria were selected from October 2019 to December 2020 in the outpatient department of obstetrics of Guangning People’s Hospital.According to the random number table method,they were divided into two groups,the experimental group (62 cases) was treated with Compound Vitamins combined with Aspirin,and the control group (64 cases) was treated with Aspirin alone.The coagulation function,pregnancy complications,incidence of perinatal adverse events and general information of neonates were compared between the two groups.Result:Before treatment,there were no significant differences in fibrinogen (FIB) and activated partial thrombin time (APTT) between the two groups (P>0.05).At the end of pregnancy,the FIB of the experimental group was lower than that of the control group,and the APTT was longer than that of the control group,the differences were statistically significant (P<0.05).The incidence of preeclampsia was lower in the experimental group than in the control group (8.1% vs 21.9%,P<0.05),there was no significant difference in the incidence of eclampsia (1.6%) compared with the control group (10.9%) (P>0.05).The incidence of neonatal asphyxia and preterm birth in experimental group were significantly lower than those in control group (6.5% vs 23.4%,4.8% vs 18.8%,P<0.05),there were no statistically significant differences in postpartum hemorrhage,mortality in the perinatal period in experimental group (3.2%,0) and control group (7.8%,4.7%) (P>0.05).The gestational age,weight,length,head circumference at birth and Apgar score 1 min after birth in experimental group were better than those of the control group (P<0.05),and the incidence of intrauterine growth retardation of the experimental group was lower than that of the control group (1.6% vs 14.8%,P<0.05).Conclusion:Compound Vitamin combined with Aspirin can help improve the hypercoagulable state of patients with gestational hypertension,reduce the incidence of preeclampsia,reduce the occurrence of perinatal adverse events,and improve the intrauterine development of the fetus.