阻塞性睡眠呼吸暂停患者fMRI网络的小世界特性

Small-World Characteristics of fMRI Network in Patients with Obstructive Sleep Apnea

目的分析研究阻塞性睡眠呼吸暂停(OSA)患者脑功能网络的整体属性和局部属性。方法回顾分析本院收治的40例OSA患者为OSA组,以40例体检健康者为对照组,收集功能磁共振成像(fMRI)采集的颅脑信息资料,使用睡眠监测(PSG)和主观量表法对比两组患者的OSA情况,并比较分析两组患者脑功能网络整体属性和局部属性的差异。结果OSA组患者的呼吸紊乱指数(AHI)和氧减指数(ODI)均显著高于对照组(P<0.05);两组在稀疏度0.1~0.2下均表现出小世界特性(σ>1),OSA组aσ显著低于对照组(P<0.05);与对照组相比,OSA组患者左侧背外侧额上回、右侧额中回的节点效率显著降低(P<0.05),左侧岛盖部额下回和右侧眶部额下回的节点度显著降低(P<0.05),左侧眶部额上回、左侧眶部额中回和右侧颞横回的节点介数显著降低(P<0.05);OSA患者的AHI和右侧额中回的节点效率(r=-0.240,P<0.05)、左侧眶部额上回的节点介数(r=-0.249,P<0.05)以及右侧颞横回的节点介数(r=-0.286,P<0.05)呈负相关;OSA患者的ODI和右侧额中回的节点效率(r=-0.250,P<0.05)、右侧颞横回的节点介数(r=-0.272,P<0.05)呈负相关。结论OSA对脑功能网络整体属性中小世界特性造成了一定影响,认知功能相关脑区的局部属性显著降低,并且其属性与OSA患者的AHI和ODI有一定的相关性。

Objective To analyze and study the overall and local attributes of brain function network in patients with obstructive sleep apnea(OSA).Methods A total of 40 patients with OSA admitted to the hospital were enrolled as OSA group,while other 40 healthy controls were enrolled as control group.The brain data from functional magnetic resonance imaging(fMRI)were collected.OSA was compared between the two groups by polysomnography(PSG)and subjective scales.The differences in the overall and local attributes of brain function network between the two groups were compared.Results The apnea hypopnea index(AHI)and oxygen desaturation index(ODI)in OSA group were significantly higher than those in control group(P<0.05).There were small-world characteristics(σ>1)under sparsity of 0.1-0.2 in both groups.The aσin OSA group was significantly lower than that in control group(P<0.05).Compared with control group,node efficiency of left dorsolateral superior frontal gyrus and right middle frontal gyrus was significantly decreased in OSA group(P<0.05),nodal degree of left insula operculum inferior frontal gyrus and right orbital inferior frontal gyrus was significantly decreased(P<0.05),node betweenness of left orbital superior frontal gyrus,left orbital middle frontal gyrus and right temporal transverse gyrus was significantly decreased(P<0.05).AHI was negatively correlated with nodal efficiency of right middle frontal gyrus(r=-0.240,P<0.05),nodal betweenness of left orbital superior frontal gyrus(r=-0.249,P<0.05)and nodal betweenness of right temporal transverse gyrus(r=-0.286,P<0.05).ODI was negatively correlated with nodal efficiency of right middle frontal gyrus(r=-0.250,P<0.05)and nodal betweenness of right temporal transverse gyrus(r=-0.272,P<0.05).Conclusion OSA has certain effects on small-world characteristics in overall attributes of brain function network,and local attributes of brain regions related to cognitive function significantly reduce.There is certain correlation between the attributes and AHI,ODI in OSA patients.