磁共振成像动态增强联合DWI序列评估乳腺癌新辅助化疗中肿瘤组织变化应用可行性研究

Feasibility of Using Dynamic Enhancement of MRI Imaging Combined with DWI Sequence to Evaluate Changes of Tumor Tissue in Neoadjuvant Chemotherapy of Breast Cancer

目的分析MRI成像动态增强联合DWI序列评估乳腺癌新辅助化疗(NAC)中肿瘤组织变化应用可行性。方法选取本院2017年4月至2019年6月收治的56例乳腺癌患者作为研究对象,进行NAC前行MRI检查。对患者所得图像进行分析,对56例患者治疗前后肿瘤ADC值、前后、左右、上下直径、总体积进行分析对比,观察治疗前后时间-信号强度曲线(TIC)曲线类型变化。结果NAC治疗后前后、左右、上下直径以及肿瘤总体积均较治疗前均有明显下降趋势(P<0.05),但治疗前后ADC值有所上升,但无明显差异(P>0.05);56例患者NAC治疗前多以TIC曲线以Ⅱ型(12例)、Ⅲ型(44例)为主,治疗后Ⅰ型11例,Ⅱ型14例,Ⅲ型31例,Ⅰ型较之前明显增多,Ⅲ型减少(P<0.05)。结论MRI成像动态增强联合DWI序列检查可直观反映出肿瘤NAC治疗后肿瘤形态学改变及TIC曲线变化,在NAC治疗中肿瘤组织变化应用可行性高。

Objective To analyze the feasibility of using dynamic enhancement of MRI imaging combined with DWI sequence to evaluate changes of tumor tissue in neoadjuvant chemotherapy of breast cancer(NAC).Methods 56 patients with breast cancer treated in our hospital from April 2017 to June 2019 were selected as the research subjects.MRI was performed before NAC.The images of the patients were analyzed.The ADC value,front and back,left and right,up and down diameter,and total volume of tumors in 56 patients before and after treatment were analyzed and compared,and the change of type in Time intensity curve(TIC)before and after treatment was observed and compared.Results After NAC treatment,front and back,left and right,up and down diameters,and total volume of tumors all showed a significant downward trend(P<0.05).However,the ADC value increased before and after treatment,but there was no significant difference(P>0.05).In 56 patients before NAC treatment,the TIC was mainly typeⅡ(12 cases)and typeⅢ(44 cases).After treatment,11 cases were typeⅠ,14 cases were typeⅡ,and 31 cases were typeⅢ.TypeⅠsignificantly increased and type Ⅲ decreased(P<0.05).Conclusion Dynamic enhancement of MRI imaging combined with DWI sequence examination can intuitively reflect changes of tumor shape and TIC after tumor NAC treatment,and it is highly feasible to evaluate changes of tumor tissue.