磁共振成像在乳腺癌分子分型中的研究进展

Research Progress of Magnetic Resonance Imaging in Molecular Typing of Breast Cancer

乳腺癌作为多基因导致的高度异质性肿瘤,其是否存在淋巴结转移、分子分型对患者治疗方案以及预后有重要影响。通过分子分型可弥补组织学分类、TNM期分类的不足,并可为患者治疗方案、转移风险、预后评估提供重要的参考资料,目前分子分型作为基础的个体化治疗评估标准越来越普及。而磁共振成像(MRI)检查利用各序列可为乳腺癌诊断提供重要参考信息,其中DCE-MRI定量参数对其分子分型评估研究前景广。而未来研究将流行病学、病理学、影像学、影像组学、分型方法等进行综合深入研究,以此确保分型的准确性、规范性,也只有对患者进行准确分子分型才能凸显出依据分子分型指导个体化治疗的精准性。

Breast cancer is a highly heterogeneous tumor caused by multiple genes.The presence or absence of lymph node metastasis and molecular typing have important effects on patients'treatment options and prognosis.Molecular typing can make up for the shortcomings of histological classification and TNM classification,and can provide important reference for patients'treatment options,passing of risk,and evaluation of prognosis.At present,molecular typing is becoming increasingly popular to be evaluative criteria of basic individualized treatments.The magnetic resonance imaging(MRI)examination uses various sequences to provide important reference information for diagnosis of breast cancer.Among them,DCE-MRI quantitative parameters have broad prospects in the evaluation of its molecular typing.In the future,comprehensive and in-depth research will be conducted on epidemiology,pathology,imaging,radiomics,and typing methods to ensure the accuracy and standardization of classification.Only by accurate molecular typing in patients,the accuracy of individualized treatment based on molecular typing may be highlighted.