盐酸利托君注射液在宫颈机能不全行紧急宫颈环扎术患者中的应用效果

Application effect of ritodrine hydrochloride injection on patients with cervical incompetence undergoing emergency cervical cerclage

目的探究盐酸利托君注射液在宫颈机能不全导致难免流产患者采取紧急宫颈环扎术的应用效果。方法回顾性分析2015年5月至2019年5月于中山市小榄人民医院妇产科就诊的宫颈机能不全患者70例,根据治疗方法不同分为A组(n=35)和B组(n=35),B组仅行紧急宫颈环扎术,A组在B组的基础上采用盐酸利托君注射液进行治疗。对比两组分娩孕周、延长妊娠时间、新生儿Apgar评分及妊娠结局(早产率、晚期流产率、足月产率)。结果A组的平均分娩孕周为(33.21±2.15)周,长于B组的(27.11±2.25)周,差异有统计学意义(P<0.05);A组的延长孕周为(48.34±2.57)d,长于B组的(16.43±2.96)d,差异有统计学意义(P<0.05);A组的Apgar评分为(8.56±0.23)分,高于B组的(7.65±0.44)分,差异有统计学意义(P<0.05);A组的早产率为2.86%,低于B组的28.86%,差异有统计学意义(P<0.05);A组的晚期流产率为0,低于B组的2.86%,差异有统计学意义(P<0.05);A组的足月产率为88.57%,高于B组的68.57%,差异有统计学意义(P<0.05)。结论宫颈机能不全患者行紧急宫颈环扎术中运用盐酸利托君注射液的疗效较为理想,可延长平均分娩孕周、提高Apgar评分、减少早产、晚期流产并增加足月产率。

Objective To explore the application effect of ritodrine hydrochloride injection in emergency cervical cerclage for patients with inevitable abortion caused by cervical incompetence.Methods A retrospective analysis was made on 70 patients with cervical incompetence treated in the Department of Obstetrics and Gynecology of Xiaolan People’s Hospital of Zhongshan from May 2015 to May 2019.According to different treatment methods,they were divided into group A(n=35)and group B(n=35).Group B was only treated with emergency cervical cerclage,while group A was given ritodrine hydrochloride injection on the basis of group B.The gestational week,prolonged pregnancy time,Apgar score of newborns and pregnancy outcome(premature delivery rate,late abortion rate and full-term birth rate)were compared between the two groups.Results The average delivery gestational weeks was(33.21±2.15)in group A,which was significantly higher than(27.11±2.25)in group B,with statistically significant difference(P<0.05).The prolonged gestational time was(48.34±2.57)d in group A,which was higher than(16.43±2.96)d in group B,with statistically significant diffe rence(P<0.05).The Apgar score was(8.56±0.23)in group A,which was higher than(7.65±0.44)in group B,with statistically significant difference(P<0.05).The premature delivery rate was 2.86%in group A,which was lower than 28.86%in group B,with statistically significant difference(P<0.05).The late abortion rate was 0 in group A,which was lower than 2.86%in group B,with statistically significant difference(P<0.05).The full-term birth rate was 88.57%in group A,which was higher than 68.57%in group B,with statistically significant difference(P<0.05).Conclusion The ritodrine hydrochloride injection exhibits an ideal curative effect in emergency cervical cerclage for patients with cervical incompetence,which can prolong the average delivery gestational week,improve Apgar score,reduce premature delivery and late abortion,increase the full-term birth rate.