代谢组学在类风湿关节炎诊断和治疗中的研究进展

Advances in application of metabolomics techniques to diagnosis and treatment of rheumatoid arthritis

类风湿关节炎(rheumatoid arthritis,RA)是一种致残率高且病因不明的慢性自身免疫性疾病,早诊断、早治疗对于预防该疾病进一步发展至关重要。近年来,代谢组学技术因其具有整体性、动态性、高灵敏度和高通量等优势广泛应用于生命科学的各个领域,该文就代谢组学技术在RA早期诊断、疾病分型、药物疗效预测与评价研究等方面的进展进行综述,以期从代谢调控角度为RA的临床诊断和治疗提供新的思路。

Rheumatoid arthritis(RA)is a chronic autoimmune disease with a high disability rate and unknown etiology.Early diagnosis and early treatment are essential to prevent the further development of the disease.In recent years,metabolomics techniques have been widely used in various fields of life sciences because of its wholism,dynamics,high sensitivity and high throughput.This article reviews the progress of metabolomics technology in various aspects of RA investigations such as early diagnosis,disease classification as well as drug efficacy prediction in order to provide new ideas for clinical diagnosis and treatment of RA from the metabolic perspective.