6例猫杯状病毒病例的诊断及治疗

Diagnosis and treatment of six feline calicivirus cases

上海市某宠物店15只猫中有6只患猫出现呼吸道症状。经临床检查发现,6只患猫体温、呼吸、心率都正常;1#、2#、3#、5#和6#患猫血常规检测正常,4#患猫血常规显示有轻度脱水。对6只患猫的样品进行猫杯状病毒核酸检测和基因测序,结果均为猫杯状病毒阳性。对6只患猫进行抗菌、点眼、清洁口腔等治疗,患猫均在10~14 d内恢复健康。调查发现,6只患猫中的4只之前已经免疫过一次猫三联疫苗,且超过21 d,另外9只健康猫都进行过2次以上的猫三联免疫。对15只猫进行猫杯状病毒抗体检测,结果6只患猫中2只未免疫的患猫和1只已免疫的患猫无抗体,1只已免疫的患猫抗体偏低,2只已免疫的患猫抗体良好;9只健康猫中1只抗体偏低,7只抗体良好,1只抗体偏高。试验表明,疫苗具有良好的免疫效果,但由于杯状病毒丰富的抗原多样性和遗传变异性,疫苗免疫无法产生针对杯状病毒感染的完全保护能力。

Six out of fifteen cats in a pet shop in Shanghai developed respiratory symptoms.The body temperature,breathing and heart rate of the six affected cats were basically normal.The routine blood test results of 1#,2#,3#,5#and 6#cats were normal,while 4#affected cat showed mild dehydration.The feline calicivirus nucleic acid detection and gene sequencing were performed on six affected cat samples,and the results were all positive.After they were treated with antibiotics,eye drops and oral cleaning agent,the six affected cats recovered within 10-14 days.Four of the six affected cats had been previously immunized(Fel-O-Vax;PCT)for more than 21 days,and nine normal cats were immunized more than twice before.15 cats were tested for calicivirus antibodies.Among the six affected cats,two unimmunized cats and one immunized cat had no antibody,one immunized cat had low antibody,and two immunized cats had good antibodies.Among the nine healthy cats,one cat had low antibody,seven cats had good antibodies,and one cat had high antibody.The above tests indicated that the vaccine had a good immune effect on cats,but due to the rich antigen diversity and genetic variability of calicivirus,the vaccine did not provide complete protection against calicivirus.