程序性细胞死亡配体-1在非小细胞肺癌中表达水平及其预后价值

The expression level of programmed cell death ligand-1 in non-small cell lung cancer and its prognostic value

目的检测程序性细胞死亡配体-1(PD-L1)在非小细胞肺癌(NSCLC)中的表达水平,分析其临床病理学特征,并探讨其与预后的相关性。方法选取潍坊市人民医院2015年1月~2020年1月期间收治的53例非小细胞肺癌患者作为研究对象进行回顾性研究,免疫组化检测NSCLC组织中PD-L1表达并将患者分为PD-L1高表达组和低表达组,研究终点为无进展生存期(PFS),采用Log-rank检验比较两组患者生存率,单因素和多因素回归分析影响NSCLC患者生存率的影响因素。结果 PD-L1高表达和低表达组的分化程度、临床分期、有无淋巴结转移比较,差异有统计学意义(P<0.05),患者的性别、年龄、吸烟情况、病理类型、肿瘤大小、EGFR表达比较,差异无统计学意义(P>0.05)。结论 PD-L1在NSCLC组织中的表达可能参与肿瘤的发生发展,对患者的预后有预测价值。

Objective To detect the expression of programmed cell death ligand-1(PD-L1) in non-small cell lung cancer(NSCLC),and analyze its clinicopathological characteristics and correlation with clinical outcome.Methods Fifty-three patients with non-small cell lung cancer admitted to Weifang People’s Hospital from January 2015 to January 2020 were selected as the subjects for a retrospective study.The patients were stratified according to the expression of PD-L1 in NSCLC tissues detected by immunohistochemistry and divided into PD-L1 high expression group and low expression group.The endpoint of the study was progression-free survival(PFS).The survival rates were compared by Log-rank test and its influence factor was analyzed by single factor and multivariate regression analysis.Results The PD-L1 high expression and low expression groups had statistically significant differences in the degree of differentiation, clinical stage and presence or absence of lymph node metastasis(P<0.05).The differences in the patient’s gender, age, smoking status, pathological type, tumor size and EGFR expression was not statistically significant(P>0.05).Conclusion This observation supports the hypothesis that the expression of PD-L1 in NSCLC tissues may be involved in the occurrence and development of tumors, and has predictive value for the clinical outcome of patients.