中国结直肠肿瘤综合预防共识意见(2021年,上海)

Chinese Consensus on Prevention of Colorectal Neoplasia(2021,Shanghai)

结直肠癌确诊时多已属中晚期,治疗效果不佳,因此其早期发现和及早预防至关重要。与其他肿瘤一样,结直肠癌也有三级预防:一级预防是病因预防,主要是针对腺瘤或炎症的治疗,阻断其发展为癌;二级预防是早诊断、早治疗,即早期发现结直肠癌并及时干预处理,以免进入进展期(中晚期);三级预防属于广义的预防范畴,主要是对于进展期结直肠癌,通过外科手术并在术后进行辅助化疗、放疗或靶向治疗、免疫治疗等以预防肿瘤再发或转移。本共识意见系参考近期国内外相关共识指南,综合近5年国际和国内相关研究的新进展而形成。共识意见研讨会由中华医学会消化病学分会及其消化系统肿瘤协作组主办,上海交通大学医学院附属仁济医院消化内科暨上海市消化疾病研究所承办。本共识意见包含60项陈述条款,陈述的循证医学等级、表决等级标准和依据均符合国际有关规定和惯例。

Most patients with colorectal cancer were diagnosed in advanced stage and the prognosis is poor.Therefore,early detection and prevention of colorectal cancer are very important.As with other cancers,there is also the tertiary prevention for colorectal cancer.The primary prevention is the etiological prevention,which is mainly the treatment of adenoma or inflammation for preventing the development into cancer.The secondary prevention is the early diagnosis and early treatment for avoiding progressing to advanced cancer.The tertiary prevention belongs to the broad category of prevention,mainly for advanced colorectal cancer,through surgical treatment and postoperative adjuvant chemotherapy,radiotherapy,targeted therapy,immunotherapy for preventing tumor recurrence or metastasis.This consensus is based on the recent domestic and international consensus guidelines and the latest progress of international researches in the past five years.The consensus opinion seminar was hosted by the Chinese Society of Gastroenterology and Cancer Collaboration Group of Chinese Society of Gastroenterology,and was organized by Division of Gastroenterology and Hepatology&Shanghai Institute of Digestive Disease,Renji Hospital,School of Medicine,Shanghai Jiao Tong University.The consensus opinion contains 60 statement clauses,the standard and basis of the evidence-based medicine grade and voting grade of the statement strictly complied with the relevant international regulations and practice.