MicroRNA在尤文肉瘤中的研究进展

Research progress of microRNA in Ewing′s sarcoma

尤文肉瘤(ES)是一种常见于儿童和青少年的骨与软组织肿瘤。ES的治疗目前采取化疗、局部手术切除、放射治疗的联合治疗方案。但患者5年生存率最高仍只能达到75%左右。微小RNA是一种小型的非编码RNA,在尤文肉瘤中参与了广泛的生物学过程,如增殖、侵袭、分化和凋亡等。文章主要对近年来中miRNA在尤文肉瘤中的研究进展进行综述。

Ewing′s sarcoma(Ewing′s sarcoma,ES)is a bone and soft tissue tumor,that is common in children and adolescents.Ewing′s sarcoma is currently treated with a combination of chemotherapy,local surgical resection and radiotherapy.However,the highest five-year survival rate of patients can only reach about 75%.MicroRNA(miRNA)is a small non-coding RNA,that participates in a wide range of biological processes in Ewing′s sarcoma,such as proliferation,invasion,differentiation and apoptosis.This manuscript reviews the research progress of miRNA in Ewing′s sarcoma in recent years to provide a new direction for the diagnosis and treatment of Ewing′s sarcoma.