肿瘤标志物、血清炎症因子和协同共刺激分子B7-H6的表达在宫颈癌中的临床价值研究

Clinical value of tumor markers,serum inflammatory factors and co-stimulatory molecule B7-H6 expression in cervical cancer

目的:探讨肿瘤标志物、血清炎症因子和协同共刺激分子B7-H6的表达在宫颈癌中的临床价值。方法:回顾性收集2019年6月至2020年9月于石家庄市妇幼保健院住院的宫颈病变患者80例,依据病理学检测结果分为宫颈癌组40例和宫颈慢性病变(宫颈良性组)40例;另选取40例同期体检正常人群作为对照组。比较3组肿瘤标志物[鳞状细胞癌抗原(SCCA)、癌胚抗原(CEA)、糖链抗原125(CA125)]水平,血清炎症因子[白介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)]水平以及B7-H6表达。结果:与对照组比较,宫颈癌组与宫颈良性组SCCA、CEA、CA125、TNF-α、B7-H6表达水平均显著升高(P<0.05);且宫颈癌组SCCA、CEA、CA125、TNF-α、B7-H6表达水平显著高于宫颈良性组,差异有统计学意义(P<0.05)。与对照组比较,宫颈癌组和宫颈良性组IL-2、IFN-γ表达水平均显著降低;且宫颈癌组IL-2、IFN-γ表达水平显著低于宫颈良性组,差异均有统计学意义(P<0.05)。结论:肿瘤标志物(SCCA、CEA、CA125)、血清炎症因子(IL-2、IFN-γ、TNF-α)和协同共刺激分子B7-H6表达水平与宫颈癌的发展密切相关,可作为宫颈癌临床诊断的重要辅助指标。

Objective:To explore the clinical value of tumor markers,serum inflammatory factors and costimulatory molecule B7-H6 expression in cervical.Methods:A retrospective collection of 80 patients with cervical cancer lesions hospitalized in Shijiazhuang Maternity and Child Healthcare Hospital from June 2019 to September 2020.According to the pathological results,they were divided into 40 cases of cervical cancer group and40 cases of cervical benign group.Another 40 cases who were taking normal physical examination during the same period were selected as the control group.We compared the levels of tumor markers[squamous cell carcinoma antigen(SCCA),carcinoembryonic antigen(CEA),sugar chain antigen 125(CA125)],serum inflammatory factor[interleukin-2(IL-2),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)]levels and the expression of costimulatory molecule B7-H6 among the three groups.Results:Compared with the control group,the expression levels of SCCA,CEA,CA125,TNF-α,B7-H6 in the cervical cancer group and the cervical benign group were significantly increased;and the levels of SCCA,CEA,CA125,TNF-α,B7-H6 in cervical cancer group were significantly higher than those of the cervical benign group;all the differences were statistically significant(P<0.05).Compared with the control group,the expression levels of IL-2 and IFN-γin the cervical cancer group and the benign cervical group were significantly lower;and the expression levels of IL-2 and IFN-γin the cervical cancer group were significantly lower than those in the benign cervical group;and all the differences were statistically significant(all P<0.05).Conclusion:The expression levels of tumor markers(SCCA,CEA,CA125),serum inflammatory factors(IL-2,IFN-γ,TNF-α)and costimulatory molecule B7-H6 are closely related to the development of cervical cancer and can be important auxiliary indexes for clinical diagnosis.