炎症在睑板腺功能障碍发病机制中的作用

Role of inflammation in pathogenesis of meibomian gland dysfunction

睑板腺功能障碍(meibomian gland dysfunction,MGD)是干眼症的主要原因,其主要发生机制是睑板腺终末导管的角化和阻塞以及睑酯分泌物的质和量改变。睑板腺对炎症刺激的自身反应、具有抗菌抗炎特性的睑酯、雄激素以及参与调控炎症的过氧化物酶体增生物激活受体γ可能介导睑板腺抵抗炎性细胞浸润的过程。睑板腺菌群失调和蠕形螨感染会诱发炎症进而影响MGD的发生发展。明确炎症在MGD中的作用和机制,将为MGD的防治提供新的思路和理论基础。

Meibomian gland dysfunction(MGD)is the main cause of dry eye and is also a common disease in ophthalmology clinic.The main mechanism of MGD is terminal duct obstruction and/or qualitative/quantitative changes in the glandular secretion.The response of meibomian gland to inflammatory stimuli,the antibacterial and anti-inflammatory meibum,androgens and peroxisome proliferator-activated receptor gamma(PPAR-γ)involved in the regulation of inflammation may mediate the meibomian gland's resistance to inflammatory cell infiltration.Dysbacteriosis of meibomian gland and infection of demodex can induce inflammation and thus affect the pathogenesis and development of MGD.To clarify the role and mechanism of inflammation in MGD will provide new ideas and theoretical basis for the prevention and treatment of MGD.