黏蛋白与眼表疾病

Mucins and ocular surface disease

眼表黏蛋白是一组高分子量糖蛋白,在眼表广泛存在,分为分泌型和膜相关型黏蛋白两大类,在润滑眼表及维持眼表稳态中发挥重要作用。眼表黏蛋白与眼表多种疾病密切相关,包括干眼、感染、过敏以及免疫相关疾病等。黏蛋白能连接水分成胶,防止泪液蒸发;并能与多种炎性因子相互作用,在维持眼表上皮细胞屏障中发挥重要作用。此外还能参与细胞内信号传导,具有抗感染等作用。促进黏蛋白分泌的药物有地夸磷索钠、瑞巴派特、神经生长因子以及胸腺素等。这些药物的出现,为干眼等多种眼表疾病带来了更多的治疗靶点。

Ocular surface mucins are a group of large and complex heavily glycosylated proteins,that cover all the surface of ocular.They can be divided into secretory mucins and membrane-associated mucins,which play a key role to lubricate and maintain integrity of the ocular surface.Ocular surface mucins are closely related to ocular surface diseases,including dry eye,infection,allergy and immune diseases.Mucins can connect water into glue,prevent the evaporation of tear.They also interact with a variety of inflammatory factors and play an important role in maintaining the epithelial cell barrier of the ocular surface.In addition,mucins can also participate in intracellular signal transduction and play an anti-infection role.To date,many medicines have been observed as secretagogues of mucins,such as diquafosol sodium,rebamipide,nerve growth factor and thymosin,etc.The emergence of these drugs has brought more therapeutic targets for many ocular surface diseases such as dry eye.