无阿片类药物的全身麻醉策略在围术期应用的可行性研究

Feasibility study on perioperative use of opiate-free general anesthesia strategy

出现严重的阿片类药物相关不良反应是影响患者手术麻醉后恢复的重要原因之一。减少阿片类药物的使用是减轻麻醉后患者相关不良反应的主要手段,但因此产生的镇痛不足可导致患者出现强烈的应激反应,同样不利于其术后恢复。近几年,随着术后加速康复(ERAS)理念的提出,多模式镇痛逐渐被应用于临床全身麻醉中。多模式镇痛在全身麻醉中的应用为全身麻醉中减少阿片类药物的使用或不用阿片类药物提供了理论依据。本文主要是对无阿片类药物的全身麻醉在围手术期应用可行性的研究进展进行综述。

Severe opioid-related adverse reactions are one of the important factors affecting the recovery of patients after surgical anesthesia.Reducing the use of opioids is the main means to alleviate the adverse reactions of patients after anesthesia,but the resulting lack of analgesia can lead to a strong stress response in patients,which is also not conducive to their postoperative recovery.In recent years,with the concept of Accelerated postoperative recovery(ERAS),multi-mode analgesia has been gradually applied in clinical general anesthesia.The application of multi-mode analgesia in general anesthesia provides a theoretical basis for reducing the use of opioids or not using opioids in general anesthesia.This article reviews the research progress on the feasibility of general anesthesia without opioids in perioperative period.