探讨子宫内膜异位症患者在行腹腔镜术后应用促性腺激素释放激素激动剂(GnRH-a)对患者妊娠及复发风险的影响

Investigate the Effect of Gonadotropin-releasing Hormone Agonist (GnRH-a) on Pregnancy and Recurrence Risk in Patients with Endometriosis after Laparoscopic Surgery

目的 分析探讨子宫内膜异位症患者在行腹腔镜术后应用促性腺激素释放激素激动剂(GnRH-a)对患者妊娠及复发风险的影响。方法 选取我院2013-2020年接收治疗子宫内膜异位症患者200例,随机将其分为观察组与对照组,对照组治疗方法为仅行腹腔镜术,观察组治疗方法为患者行腹腔镜术后,从患者恢复月经的第1天开始,每隔4周注射1次GnRH-a3.75 mg,疗程为3个月。统计分析患者术后1年内的调查资料,比较两组患者接受治疗后的疼痛感、复发率、妊娠率与患者接受治疗后生活质量的变化,将治疗效果分为显效、有效、无效3个层次。结果 观察组患者无疼痛感与疼痛感弱的患者人数均高于对照组,两组数据差异有统计意义(P<0.05)。统计其术后妊娠率与复发率,观察组复发率低于对照组,妊娠率高于对照组,两组数据差异有统计意义(P<0.05)。观察组患者术后生活质量均高于对照组,两组数据差异有统计意义(P<0.05)。观察组总有效率高于对照组,两组数据差异有统计意义(P<0.05)。结论 术后应用促性腺激素释放激素激动剂对治疗子宫内膜异位症效果更加有效,可以明显降低患者疼痛感,减少复发率,提高术后妊娠率,值得在治疗子宫内膜异位症临床中推广与应用。

Objective To analyze the effect of gonadotropin-releasing hormone agonist (GnRH-a) on pregnancy and recurrence risk in patients with endometriosis after laparoscopic surgery.Methods Two hundred patients with endometriosis in our hospital from 2013 to 2020 were selected and randomly divided into observation group and control group.The control group was treated only by laparoscopy,and the observation group was treated by laparoscopy.From the first day of menstruation recovery,GnRH-a 3.75 mg was injected every 4 weeks for 3 months.The pain,recurrence rate,pregnancy rate and quality of life after treatment were compared between the two groups.The treatment effect was divided into three parts:markedly effective,effective and ineffective.Results The number of patients with no pain and weak pain in the observation group was higher than that in the control group,and the difference between the two groups was statistically significant (P<0.05).The recurrence rate of the observation group was lower than that of the control group,the pregnancy rate was higher than that of the control group,the difference was statistically significant (P<0.05).The quality of life of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference between the two groups was statistically significant (P<0.05).Conclusion Postoperative application of gonadotropin-releasing hormone agonist is more effective in the treatment of endometriosis,which can significantly reduce the pain of patients,reduce the recurrence rate,and improve the postoperative pregnancy rate,which is worthy of promotion and application in the treatment of endometriosis.