免疫学检验联合检测诊断类风湿关节炎的临床价值研究

Clinical value of combined detection of immunological test in the diagnosis of rheumatoid arthritis

目的研究免疫学检验联合检测诊断类风湿关节炎(RA)的临床价值。方法40例进行体检的健康人员作为参照组,同期40例类风湿关节炎患者作为研究组。两组受检者均接受免疫学检验联合检测,分析检验结果。比较两组类风湿因子(RF)、抗环瓜氨酸多肽抗体(抗CCP)、抗角蛋白抗体(AKA)阳性检出率,免疫球蛋白G(IgG)、补体C3、补体C4水平。结果研究组的RF、抗CCP、AKA阳性检出率分别为85.00%、62.50%、85.00%,均高于参照组的2.50%、5.00%、0,差异具有统计学意义(P<0.05)。研究组的IgG为(15.64±4.71)g/L、补体C3为(0.68±0.25)g/L、补体C4为(0.14±0.05)g/L,参照组的IgG为(10.47±3.08)g/L、补体C3为(1.23±0.31)g/L、补体C4为(0.29±0.17)g/L。研究组的IgG高于参照组,补体C3、补体C4低于参照组,差异具有统计学意义(P<0.05)。结论采用免疫学检验联合检测诊断类风湿关节炎的准确率较高,临床可以将其作为类风湿关节炎诊断的有效方案,为患者的疾病治疗提供参考。

Objective To study the clinical value of combined detection of immunological test in the diagnosis of rheumatoid arthritis(RA).Methods 40 healthy persons who underwent physical examination were used as the reference group,and 40 patients with rheumatoid arthritis during the same period were used as the research group.Both groups underwent combined detection of immunological test to analyze the test results.Both groups were compared in terms of positive detection rates of rheumatoid factor(RF),anti-cyclic citrulline peptide antibody(anti-CCP),anti-keratin antibody(AKA),and the levels of immunoglobulin G(IgG),complement C3,and complement C4.Results The positive detection rates of RF,anti-CCP,and AKA in the research group were 85.00%,62.50%,and 85.00%,which were higher than 2.50%,5.00%,and 0 of the reference group,and the difference was statistically significant(P<0.05).The IgG,complement C3 and complement C4 of the research group were(15.64±4.71),(0.68±0.25),and(0.14±0.05)g/L,which were(10.47±3.08)g/L,(1.23±0.31)and(0.29±0.17)g/L of the reference group.The IgG of the research group was higher than that of the reference group,and the complement C3 and complement C4 were lower than those of the reference group.All the differences were statistically significant(P<0.05).Conclusion Combined detection of immunological test has high accuracy in the diagnosis of rheumatoid arthritis,which can be used as an effective scheme for the diagnosis of rheumatoid arthritis and provide a reference for the disease treatment of patients.