阿卡波糖+二甲双胍治疗2型糖尿病伴高脂血症的疗效和安全性分析

Efficacy and safety analysis of acarbose combined with metformin in the treatment of type 2 diabetes mellitus with hyperlipidemia

目的分析阿卡波糖+二甲双胍治疗2型糖尿病伴高脂血症的疗效和安全性。方法108例2型糖尿病伴高脂血症患者作为研究对象,采用随机数字表法分为对照组和观察组,每组54例。对照组患者接受二甲双胍治疗,观察组患者接受阿卡波糖联合二甲双胍治疗。对比两组患者不良反应发生情况、治疗后血糖(空腹血糖、餐后2 h血糖、糖化血红蛋白)水平、治疗后血脂[血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平。结果观察组不良反应发生率9.26%高于对照组的7.41%,但比较差异无统计学意义(P>0.05)。观察组患者治疗后的空腹血糖、餐后2 h血糖、糖化血红蛋白分别为(8.75±0.86)mmol/L、(12.55±1.14)mmol/L、(6.86±0.67)%,均低于对照组的(12.87±1.19)mmol/L、(15.29±1.38)mmol/L、(9.00±0.85)%,差异统计学有意义(P<0.05)。观察组患者治疗后的TC、TG、LDL-C分别为(7.09±0.68)、(1.63±0.15)、(3.35±0.31)mmol/L均低于对照组的(8.82±0.87)、(3.14±0.29)、(4.39±0.42)mmol/L,HDL-C(1.55±0.13)mmol/L高于对照组的(1.15±0.10)mmol/L,差异统计学有意义(P<0.05)。结论2型糖尿病伴高脂血症患者接受阿卡波糖联合二甲双胍治疗,能够有效降低其血脂水平和血糖水平,且治疗期间的不良反应较少。

Objective To analyze the efficacy and safety of acarbose combined with metformin in the treatment of type 2 diabetes mellitus with hyperlipidemia.Methods A total of 108 patients with type 2 diabetes mellitus and hyperlipidemia as the research subjects were divided into control group and observation group by random numerical table,with 54 cases in each group.Patients in the control group received metformin treatment,and patients in the observation group received acarbose combined with metformin treatment.Both groups were compared in terms of occurrence of adverse reactions,blood glucose (fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin),and blood lipids [serum total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]after treatment.Results The incidence of adverse reactions 9.26%in the observation group was higher than 7.41%in the control group,but the difference was not statistically significant(P>0.05).After treatment,the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin of the observation group were(8.75±0.86)mmol/L,(12.55±1.14)mmol/L,and(6.86±0.67)%,which were lower than(12.87±1.19)mmol/L,(15.29±1.38)mmol/L,(9.00±0.85)%of the control group,and the difference was statistically significant(P<0.05).After treatment,the TC,TG,LDL-C of the observation group were(7.09±0.68),(1.63±0.15),(3.35±0.31)mmol/L,which were lower than(8.82±0.87),(3.14±0.29),(4.39±0.42)mmol/L of the control group,and the HDL-C(1.55±0.13)mmol/L was higher than(1.15±0.10)mmol/L of the control group.All the differences were statistically significant(P<0.05).Conclusion Acarbose in combination with metformin for patients with type 2 diabetes mellitus and hyperlipidemia can effectively reduce their lipid levels and blood glucose levels with fewer adverse reactions during treatment.