《食物蛋白诱导性小肠结肠炎综合征诊断和治疗国际共识指南》解读

Interpretation of“International Consensus Guidelines for Diagnosis and Treatment of Food Protein-Induced Enterocolitis Syndrome”

食物蛋白诱导性小肠结肠炎综合征(FPIES)是一种重要的非IgE介导的食物过敏反应,常见于婴幼儿,急性发作时严重者会出现脱水、休克,慢性病程者可能出现生长发育迟缓。2017年,美国变态反应、哮喘和免疫学会下属的食物不良反应委员会联合国际FPIES协会制定并发布了迄今为止唯一一部FPIES诊治指南--《食物蛋白诱导性小肠结肠炎综合征诊断和治疗国际共识指南》。该指南基于文献回顾和临床证据提出了30条意见,为FPIES的临床诊治提供了参考依据。目前,国内医护人员对FPIES的知晓率较低,相关研究很少。该文围绕FPIES的临床表现、诊断、辅助检查、治疗以及预后等方面对该指南进行了详细解读,以加深国内医护人员对FPIES的认识,提高其诊治能力。

Food protein-induced enterocolitis syndrome(FPIES)is a critical non-IgE-mediated food allergy,occurs mostly in infants.Dehydration shock may occur in severe FPIES cases upon acute onset,and growth retardation probably occurs in patients with chronic FPIES.In 2017,Adverse Reactions to Foods Committee,American College of Allergy,Asthma and Immunology and International FPIES Association jointly formulated and released International Consensus Guidelines for Diagnosis and Treatment of Food Protein-induced Enterocolitis Syndrome,which is the only diagnosis and treatment guidelines for FPIES.Based on literature review and clinical evidence,this guideline proposes 30 statements,which provide reference for clinical diagnosis and treatment of FPIES.At present,medical staff has a low awareness rate of FPIES,and relevant studies are still lacking in China.In this article,clinical manifestations,diagnosis,auxiliary examination,treatment and prognosis of FPIES were explicitly interpreted,aiming to deepen the understanding of FPIES and improve the diagnosis and treatment levels among Chinese medical staff.