应用多维度智能化平台提高儿童皮下免疫治疗依从性的研究

Evaluation of multi-dimensional intelligent management in improving compliance of subcutaneous specific immunotherapy in children

目的探讨多维度智能化平台对提高儿童皮下免疫治疗(SCIT)的治疗依从性的效果。方法选取被诊断为变应性鼻炎(AR)和(或)过敏性哮喘(AS)并接受SCIT的162例患儿为研究对象,在常规处理基础上增加多维度智能化平台干预的85例患儿被纳入智能组,仅予常规处理的77例患儿被纳入传统组。比较2组患儿初始治疗阶段脱落率、进入维持治疗阶段所用时间,对患儿进行SCIT疗效评估,包括AR症状评分、AS日间及夜间症状评分、疼痛视觉模拟评分法(VAS)评分及药物评分,比较2组各量表评分在开始SCIT时及进入维持治疗阶段时的改善情况,并比较2组的满意度。结果智能组和传统组患儿SCIT的初始治疗阶段脱落率比较差异有统计学意义(0.0%vs.7.8%,P<0.01)。智能组达到维持治疗阶段所用时间短于传统组[15(15,16)周vs.16(15,18)周,P<0.01]。进入维持治疗阶段时智能组AR症状评分、AS日间及夜间症状评分、VAS、药物评分及满意度均优于传统组(P均<0.01)。结论多维度智能化平台有助于提高接受SCIT患儿的治疗依从性、缩短进入维持治疗阶段所用时间、提高治疗效果及患者满意度。

Objective To evaluate the effect of multi-dimensional intelligent management on improving the compliance of subcutaneous specific immunotherapy(SCIT)in children.Methods 162 children diagnosed with allergic rhinitis(AR)and(or)allergic asthma(AS)receiving SCIT were recruited in this study.85 children received routine management combined with multi-dimensional intelligent management were assigned into the intelligent group and 77 children received routine management were allocated into the control group.The SCIT shedding rate in the initial treatment stage and the time taken to reach the maintenance phase were compared between two groups.The clinical efficacy of SCIT in children was assessed by the symptom score for AR,AS symptom scores(daytime and nighttime),visual analogue scale(VAS)score and medication score were compared between two groups.The improvement of the scores of each scale from the beginning of SCIT to the maintenance treatment was evaluated and compared between two groups.The degree of satisfaction was also statistically compared between two groups.Results There were significant differences in shedding rate during the initial treatment stage(0.0%vs.7.8%,P<0.01),the time taken to reach the maintenance treatment stage(15(15,16)weeks vs.16(15,18)weeks,P<0.01)between two groups.The symptom score for AR,AS symptom scores(daytime and nighttime),VAS score,medication score and degree of satisfaction in the intelligent group were superior to those in the control group(all P<0.01).Conclusion Application of multi-dimensional intelligent management contributes to improving the compliance of SCIT,shortening the time taken to reach the maintenance phase,enhancing clinical efficacy and degree of satisfaction in children with airway allergic diseases.