银杏内酯对血管性痴呆患者认知功能及血脂水平的影响

Effect of ginkgolide on cognitive function and blood lipid level in patients with vascular dementia

目的探究银杏内酯对血管性痴呆患者认知功能及血脂水平的影响。方法69例血管性痴呆患者,按随机数字表法分为对照组(34例)和观察组(35例)。对照组患者接受常规治疗,观察组患者在常规治疗的基础上联合银杏内酯治疗。比较两组患者临床疗效、治疗前后的认知功能以及血脂水平。结果观察组治疗总有效率91.43%高于对照组的70.59%,差异有统计学意义(P<0.05)。治疗后,两组患者简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分均较本组治疗前升高,且观察组患者MMSE评分(25.47±4.43)分、MoCA评分(21.89±4.74)分高于对照组的(21.58±3.89)、(19.38±3.64)分,差异有统计学意义(P<0.05)。治疗后,两组患者甘油三酯(TG)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)均较本组治疗前降低,高密度脂蛋白胆固醇(HDL-C)均较本组治疗前升高,且观察组TG(1.32±0.31)mmol/L、TC(3.38±0.85)mmol/L、LDL-C(1.72±0.54)mmol/L低于对照组的(1.96±0.45)、(4.51±0.65)、(2.25±0.68)mmol/L,HDL-C(1.75±0.28)mmol/L高于对照组的(1.21±0.49)mmol/L,差异有统计学意义(P<0.05)。结论血管性痴呆患者应用银杏内酯治疗可有效提高其认知功能,改善生活质量,同时可调节血脂水平,疗效显著。

Objective To investigate the effect of ginkgolide on cognitive function and blood lipid level in patients with vascular dementia.Methods A total of 69 patients with vascular dementia were divided into control group(34 cases)and observation group(35 cases)according to the random numerical table.Patients in the control group received conventional treatment,and patients in the observation group were treated with ginkgolide on the basis of conventional treatment.The clinical efficacy,cognitive function and blood lipid levels before and after treatment were compared between the two groups.Results The total effective rate of treatment 91.43%of the observation group was higher than 70.59%of the control group,and the difference was statistically significant(P<0.05).After treatment,the mini mental state examination(MMSE)score and Montreal cognitive assessment scale(MoCA)score of the two groups were higher than those of this group before treatment;the MMSE score(25.47±4.43)points and MoCA score(21.89±4.74)points of the observation group were higher than(21.58±3.89)and(19.38±3.64)points of the control group;all the differences were statistically significant(P<0.05).After treatment,the triglycerides(TG),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)of the two groups were lower than those of this group before treatment,and the high-density lipoprotein cholesterol(HDL-C)was lower than that of this group before treatment;the TG(1.32±0.31)mmol/L,TC(3.38±0.85)mmol/L,LDL-C(1.72±0.54)mmol/L of the observation group were lower than(1.96±0.45),(4.51±0.65),(2.25±0.68)mmol/L of the control group,and the HDL-C(1.75±0.28)mmol/L was higher than(1.21±0.49)mmol/L of the control group;all the differences were statistically significant(P<0.05).Conclusion Ginkgolide can effectively improve the cognitive function,improve the quality of life,regulate the level of blood lipids in patients with vascular dementia,and the efficacy is significant.