喹硫平治疗首发精神分裂症患者改善睡眠质量的效果观察

On the Subjective and Objective Effects of Risperidone and Quetiapine in the Treatment of First-episode Schizophrenia Effects of Sleep

目的:探究分析对首发精神分裂症患者采取利培酮与喹硫平治疗对于改善主客观睡眠质量的效果。方法:选取2019年4月至2020年4月广西柳州钢铁集团有限公司医院收治的首发精神分裂症患者180例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组90例。对照组患者给予利培酮治疗,观察组患者给予喹硫平治疗,观察比较2组患者的治疗效果以及对睡眠质量的改善作用。结果:2组患者的治疗总有效率均较高,2组比较差异无统计学意义(P>0.05);治疗后,2组患者的匹兹堡睡眠质量指数(PSQI)评分均有所改善,且观察组的改善效果优于对照组,2组比较差异有统计学意义(P<0.05)。结论:对首发精神分裂症患者采取利培酮与喹硫平治疗都可以取得较好的治疗效果,但在改善睡眠质量方面,喹硫平的作用更加显著。

Objective:To explore and analyze the effect of risperidone and quetiapine on improving subjective and objective sleep quality in patients with first-episode schizophrenia.Methods:180 cases of first-episode schizophrenic patients in Hospital of Guangxi Liuzhou Iron and Steel Group Co.,Ltd.from April 2019 to April 2020 were selected as the data source of this study.According to the random number table method,they were divided into control group and observation group,90 cases in each group.The control group was given risperidone treatment,and the observation group was given quetiapine treatment。Results:The total effective rate of the control group and the observation group were higher,and the difference was not statistically significant(P>0.05);after treatment,the Pittsburgh sleep quality index(PSQI)scores of the two groups were improved,and the improvement effect of the observation group was better than that of the control group,with statistical significance(P<0.05).Conclusion:risperidone and quetiapine can achieve good therapeutic effect in the treatment of first-episode schizophrenia,but quetiapine is more effective in improving subjective and objective sleep quality.