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重组人干扰素α2b喷雾剂联合异丙托溴铵在小儿毛细支气管炎治疗中的效果观察

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摘要 目的探究重组人干扰素α2b喷雾剂联合异丙托溴铵在小儿毛细支气管炎治疗中的效果。方法选取就诊的200例小儿毛细支气管炎患儿为研究对象,按随机数字表法分成对照组和观察组各100例。对照组基于常规治疗采用异丙托溴铵治疗,观察组基于对照组采用重组人干扰素α2b喷雾剂治疗,疗程1周。比较两组治疗1周临床疗效,治疗前及治疗1周血清指标[免疫球蛋白G(IgG)、免疫球蛋白E(IgE)、肿瘤坏死因子-α(TNF-α)]水平及治疗期间不良反应发生情况。结果治疗1周,观察组整体治疗效果优于对照组,差异有统计学意义(P<0.05);治疗1周,两组IgG水平高于治疗前,IgE、TNF-α水平低于治疗前,且观察组IgG水平高于对照组,IgE、TNF-α水平低于对照组,差异有统计学意义(P<0.05);两组治疗期间未发生明显不良反应。结论重组人干扰素α2b喷雾剂联合异丙托溴铵在小儿毛细支气管炎治疗中,可降低患儿机体炎症反应,改善其免疫功能,提高临床疗效,安全性高。
作者 高晓彩
出处 《现代诊断与治疗》 CAS 2021年第23期3757-3759,共3页 Modern Diagnosis and Treatment
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  • 1Xiao-Mei Zhang,Ai-Zhen Lu,Hao-Wei Yang,Li-Ling Qian,Li-Bo Wang,Xiao-Bo Zhang.Clinical features of postinfectious bronchiolitis obliterans in children undergoing long-term nebulization treatment[J].World Journal of Pediatrics,2018,14(5):498-503. 被引量:22
  • 2Ralston SL, Lieberthal AS, Meissner HC, et al. Clinical practice guideline : the diagnosis, management, and prevention of bronchiolitis[ J]. Pediatrics,2014,134(5) : e1474-e1502.
  • 3Zorc JJ, Hall CB. Bronehiolitis: recent evidence on diagnosis and management [ J ]. Pediatrics,2010,125 (2) : 342-349.
  • 4Marguet C, Lubrano M, Gueudin M, et al. In very young infants severity of acute bronchiolitis depends on carried viruses [ J ]. PLoS ONE,2009,4(2) : e4596.
  • 5Corsello G, Di Carlo P, Salsa L, et al. Respiratory syncytial virus infection in a Sicilian pediatric population : risk factors, epidemiology, and severity [ J ]. Allergy Asthma Proc, 2008,29 (2) : 205-210.
  • 6Hindiyeh M, Keller N, Mandelboim M, et al. High rate of human bocavirus and adenovirus coinfection in hospitalized Israeli children[J]. J Clin Microbiol,2008,46( 1 ) : 334-337.
  • 7Scottish Intercollegiate Guidelines Network. Bronchiolitis in Children [ S/OL]. 2006, [2015-2-13] ,1-46. www. sign. ac. uk.
  • 8w Paediatric Society New Zealand: Guidelines; Wheeze and Chest infection in Children Under 1 Year [ S/OL]. 2005, [ 2015-2-13 ], 1-53. www. paediatrics, org. nz.
  • 9Ricart S, Marcos MA, Sarda M, et al. Clinical risk factors are more relevant than respiratory viruses in predicting bronchiolitis severity. Pediatr Pulmonol, 2013, 48 (5) :456463.
  • 10American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Subcommittee on diagnosis and management of bronchiolitis [ J ]. Pediatrics, 2006, 118 ( 4 ) : 1774-1793.

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