左卡尼汀联合促红细胞生成素对尿毒症血液透析患者肾功能和T细胞亚群的影响

Effects of L-carnitine Combined with Erythropoietin on Renal Function and T Cell Subsets in Uremic Hemodialysis Patients

目的观察左卡尼汀联合促红细胞生成素对尿毒症血液透析患者T细胞亚群和肾功能的影响。方法选择2019年1月至2020年2月重庆市渝北区人民医院收治的尿毒症血液透析患者93例,按照随机数字表法分为对照组46例(促红细胞生成素治疗)和观察组47例(左卡尼汀+促红细胞生成素治疗),对比两组疗效、肾功能、T细胞亚群以及不良反应。结果观察组治疗6个月后的临床总有效率为89.36%,高于对照组的67.39%(P<0.05)。两组治疗6个月后尿素氮(BUN)、血肌酐(SCr)、β-微球蛋白(β-MG)均较治疗前下降,且观察组低于对照组(P<0.05)。两组治疗6个月后CD3^(+)、CD4^(+)/CD8^(+)、CD4+均升高,且观察组高于对照组(P<0.05),CD8^(+)下降,且观察组低于对照组(P<0.05)。对照组和观察组的不良反应发生率分别为6.52%、8.51%,组间对比无明显差异(P>0.05)。结论尿毒症血液透析患者给予左卡尼汀联合促红细胞生成素治疗后,肾功能、免疫功能可得到显著改善,且安全有效。

Objective To observe the effect of L-carnitine combined with erythropoietin on T cell subsets and renal function in uremic hemodialysis patients.Methods 93 cases of uremic hemodialysis patients in Chongqing Yubei District People’s Hospital from January 2019 to February 2020 were selected and randomly divided into control group(46 cases)and observation group(47 cases)according to the random number table method.The curative effect,renal function,T cell subsets and adverse reactions of the two groups were compared.Results After 6 months of treatment,the total effective rate of the observation group was 89.36%,which was higher than 67.39%of the control group(P<0.05).After 6 months of treatment,the blood urea nitrogen(BUN),ser um creatinine(SCR)andβ-Microglobulin(β-MG)in the two groups were lower than that before treatment,and the observation group was lower than the control group(P<0.05).After 6 months of treatment,CD3^(+),CD4^(+)/CD8^(+),CD4^(+)in the two groups increased,and the observation group was higher than the control group(P<0.05),while CD8^(+)decreased,and the observation group was lower than the control group(P<0.05).The incidence of adverse reactions in the control group and the observation group were 6.52%and 8.51%respectively,and there was no significant difference between the two groups(P>0.05).Conclusion L-carnitine combined with erythropoietin can significantly improve renal function and immune function in uremic hemodialysis patients,which is safe and effective.