沙门氏菌噬菌体在动物和食品中的生物防控研究进展

Research progress on biological prevention and control of Salmonella phage in animals and foods

随着沙门氏菌耐药性持续发展、耐药菌不断出现以及食物中毒事件频发,噬菌体已成为一种新型防控耐药性沙门氏菌的生物杀菌剂。噬菌体的作用机制与抗生素完全不同,在控制耐药性沙门氏菌感染与污染方面具有良好的应用前景,尤其在治疗超级耐药沙门氏菌方面有着极大的优势,但是由于沙门氏菌血清型众多,需要开展针对不同血清型的沙门氏菌特异性噬菌体的分离和鉴定,这样的噬菌体疗法更具有针对性,从而成功应对新出现的沙门氏菌。本文综述了沙门氏菌危害、沙门氏菌噬菌体及商用沙门氏菌噬菌体制剂的研究进展、沙门氏菌噬菌体生物防治的研究进展和最新发现,重点介绍沙门氏菌噬菌体在食品工业中的应用,为噬菌体作为抗菌剂防控沙门氏菌提供借鉴和参考。

With the continuous development and emergence of drug-resistance of Salmonella and frequent food poisoning events incidents,phage has become a new biological bactericide for the prevention and control of drug-resistant Salmonella.The bactericidal mechanism of phage is completely different from that of antibiotics.It has a good application prospect in controlling the infection and contamination of drug-resistant Salmonella,especially in the treatment of super-drug-resistant bacteria.However,due to the large numbers of Salmonella serovars,it is necessary to isolate and identify more Salmonella specific phages for different Salmonella serovars,so that phage therapy become more targeted,so as to successfully deal with novel emerging Salmonella.This review summarized the harm of Salmonella,the research progress of Salmonella phage and commercial Salmonella phage preparations,the research progress and latest discovery of the prevention and control of Salmonella phage,with emphasis on the application of Salmonella phage in food industry,so as to provide reference for phage as antibacterial agent to prevent and control Salmonella.